Carcinoma

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Carcinoma Classification and external resources
OMIM	8010/3
MeSH	D002277

A carcinoma is any malignant cancer that arises from epithelial cells. Carcinomas invade surrounding tissues and organs and may metastasize, or spread, to lymph nodes and other sites.

Carcinoma in situ (CIS) is a pre-malignant condition, in which some cytological signs of malignancy are present, but there is no histological evidence of invasion through the epithelial basement membrane.

Contents 1 Classification of carcinoma 1.1 Types of carcinoma by ICD-O Code 1.2 Types of lung carcinoma 2 Staging and grading 3 See also

[edit] Classification of carcinoma

Carcinoma, like all neoplasia, is classified by its histopathological appearance. Adenocarcinoma and squamous cell carcinoma, two common descriptive terms for tumors, reflect the fact that these cells may have glandular or squamous cell appearances respectively. Severely anaplastic tumors might be so undifferentiated that they do not have a distinct histological appearance (undifferentiated carcinoma).

Sometimes a tumour is referred to by the presumptive organ of the primary (eg carcinoma of the prostate) or the putative cell of origin (hepatocellular carcinoma, renal cell carcinoma).

[edit] Types of carcinoma by ICD-O Code

(8010-8790) Epithelial

• (8010-8040) Epithelial neoplasms, NOS
• (8050-8080) Squamous cell neoplasms
  • (M8070/3) Squamous cell carcinoma, NOS
• (8090-8110) Basal cell neoplasms
  • (M8090/3) Basal cell carcinoma, NOS
• (8120-8130) Transitional cell papillomas and carcinomas
• (8140-8380) Adenomas and Adenocarcinomas (glands)
  • (M8140/0) Adenoma, NOS
  • (M8140/3) Adenocarcinoma, NOS
  • (M8142/3) Linitis plastica
  • (M8151/0) Insulinoma, NOS
  • (M8152/0) Glucagonoma, NOS
  • (M8153/1) Gastrinoma, NOS
  • (M8155/3) Vipoma
  • (M8160/3) Cholangiocarcinoma
  • (M8170/3) Hepatocellular carcinoma, NOS
  • (M8200/3) Adenoid cystic carcinoma
  • (M8240/1) Carcinoid tumor, NOS, of appendix
  • (M8271/0) Prolactinoma
  • (M8290/0) Oncocytoma
  • (M8290/0) Hurthle cell adenoma
  • (M8312/3) Renal cell carcinoma
  • (M8312/3) Grawitz tumor
  • (M8360/1) Multiple endocrine adenomas
  • (M8380/0) Endometrioid adenoma, NOS
• (8390-8420) Adnexal and Skin appendage Neoplasms
• (8430-8439) Mucoepidermoid Neoplasms
• (8440-8490) Cystic, Mucinous and Serous Neoplasms
  • (M8440/0) Cystadenoma, NOS
  • (M8480/6) Pseudomyxoma peritonei
• (8500-8540) Ductal, Lobular and Medullary Neoplasms
• (8550-8559) Acinar cell neoplasms
• (8560-8580) Complex epithelial neoplasms
  • (M8561/0) Warthin's tumor
  • (M8580/0) Thymoma, NOS
• (8590-8670) Specialized gonadal neoplasms
  • (M8590/1) Sex cord-stromal tumor
  • (M8600/0) Thecoma, NOS
  • (M8620/1) Granulosa cell tumor, NOS
  • (M8630/1) Arrhenoblastoma, NOS
  • (M8631/0) Sertoli-Leydig cell tumor
• (8680-8710) Paragangliomas and Glomus tumors
  • (M8680/1) Paraganglioma, NOS
  • (M8700/0) Pheochromocytoma, NOS
  • (M8711/0) Glomus tumor
• (8720-8790) Nevi and Melanomas
  • (M8720/0) Melanocytic nevus
  • (M8720/3) Malignant melanoma, NOS
  • (M8720/3) Melanoma, NOS
  • (M8721/3) Nodular melanoma
  • (M8727/0) Dysplastic nevus
  • (M8742/3) Lentigo maligna melanoma
  • (M8743/3) Superficial spreading melanoma
  • (M8744/3) Acral lentiginous melanoma, malignant

[edit] Types of lung carcinoma

• Adenocarcinoma is a malignant tumor originating in the epithelial cells of glandular tissue and forming glandular structures. This is common in the lung (forming 30-40% of all lung carcinomas). It is found peripherally, arising from goblet cells or type II pneumocytes.

• Squamous cell carcinoma due to squamous metaplasia. This accounts for 20-30 percent of lung tumors and is usually hilar in origin.

• Small cell carcinoma is almost certainly due to smoking. These metastasise early, and may secrete ADH (lowering patient sodium concentration).

• Large cell undifferentiated carcinomas account for 10-15 percent of lung neoplasms. These are aggressive and difficult to recognise due to the undifferentiated nature. These are most commonly central in the lung.

• Sinonasal undifferentiated carcinoma

[edit] Staging and grading

The staging of cancers is the extent of spread of the neoplasm. Grading is the system used to record the tumors degree of differentiation from the parent tissue. High grade shows little differentiation and the prognosis is therefore poor.

Carcinomas, like all cancers, are staged according to the extent of disease. The UICC/AJCC TNM system is often used, however for some common tumors, classic staging methods (such as the Dukes classification for colon cancer) are still used.

[edit] See also

• Cancer
• Sarcoma
• Hematological malignancy
• Basal cell carcinoma

v • d • e Epithelial neoplasms (ICD-O 8010-8799) Papilloma/carcinoma (8010-8139) Small cell carcinoma - Verrucous carcinoma - Squamous cell carcinoma - Basal cell carcinoma - Transitional cell carcinoma Adenomas/adenocarcinomas (8140-8429) Linitis plastica pancreas (Insulinoma, Glucagonoma, Gastrinoma, VIPoma, Somatostatinoma) - Neuroendocrine tumors Cholangiocarcinoma - Hepatocellular adenoma/Hepatocellular carcinoma - Adenoid cystic carcinoma - Familial adenomatous polyposis - Prolactinoma - Oncocytoma - Hurthle cell - Clear cell adenoma/adenocarcinoma - Renal cell carcinoma - Multiple endocrine neoplasia - Endometrioid tumor - Apudoma Adnexal And Skin appendage (8390-8429) sweat gland (Hidrocystoma, Syringoma) Cystic, Mucinous And Serous (8440-8499) (Mucoepidermoid carcinoma - Cystadenoma/Cystadenocarcinoma/Pseudomyxoma peritonei - Signet ring cell carcinoma/Krukenberg tumor Ductal, Lobular And Medullary (8500-8549) Ductal carcinoma - Paget's disease of the breast/Extramammary Paget's disease Acinar cell (8550-8559) Acinic cell carcinoma Complex epithelial (8560-8589) Warthin's tumor - Thymoma Gonadal (8590-8679) Sex cord-stromal tumour: Thecoma - Granulosa cell tumour - Luteoma - Sertoli-Leydig cell tumour Paragangliomas And Glomus tumors (8680-8719) Paraganglioma - Pheochromocytoma - Glomus tumor Nevi and melanomas (8720-8799) Melanocytic nevus - Nodular melanoma - Dysplastic nevus - Lentigo maligna melanoma - Superficial spreading melanoma