Carboprost

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Carboprost
Systematic (IUPAC) name
(5Z,9α,11α,13E,15S)-9,11,15-trihydroxy-15- methylprosta-5,13-dien-1-oic acid
Identifiers
CAS number	58551-69-2
ATC code	G02AD04
PubChem	5284525
DrugBank	APRD00847
Chemical data
Formula	C21H36O5
Mol. mass	368.508 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status	℞ Prescription only
Routes	Intravenous

Carboprost ("carboprost tromethamine") is a synthetic prostaglandin analogue of 15-methyl-PGF2_a with oxytocic properties. Can be used to induce labor or can trigger abortion in early pregnancy. It is e.g. used in mola hydatidosa. It is also used in the treatment of postpartum bleeding. Caution in asthmatic patients. The trade name is Hemabate

[edit] External links

• MeSH Carboprost
• Indman P (2004). "Use of carboprost to facilitate hysteroscopic resection of submucous myomas.". J Am Assoc Gynecol Laparosc 11 (1): 68–72. doi:10.1016/S1074-3804(05)60014-X. PMID 15104835. 
• Vukelić J. "Second trimester pregnancy termination in primigravidas by double application of dinoprostone gel and intramuscular administration of carboprost tromethamine.". Med Pregl 54 (1-2): 11–6. PMID 11436877. 
• Ippoliti C, Przepiorka D, Mehra R, Neumann J, Wood J, Claxton D, Gajewski J, Khouri I, van Besien K, Andersson B (1995). "Intravesicular carboprost for the treatment of hemorrhagic cystitis after marrow transplantation.". Urology 46 (6): 811–5. doi:10.1016/S0090-4295(99)80349-5. PMID 7502421. 

v • d • e Eicosanoids: prostaglandins Endogenous/series 2 D2 - E2 (Dinoprostone) - F2 (Dinoprost) - H2 - I2 (Prostacyclin) Prostaglandin analogues E: Alprostadil - Enprostil - Misoprostol F: Bimatoprost - Carboprost - Latanoprost - Travoprost I: Beraprost - Epoprostenol - Iloprost - Treprostinil