CA7

From Wikipedia, the free encyclopedia

Carbonic anhydrase VII

Identifiers

CA7; CAVII

External IDs

OMIM: 114770 MGI: 103100 HomoloGene: 55875

Gene ontology
Molecular Function:	• carbonate dehydratase activity • zinc ion binding • lyase activity • metal ion binding
Biological Process:	• one-carbon compound metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001014435 (mRNA)
NP_001014435 (protein)

NM_053070 (mRNA)
NP_444300 (protein)

Location

Chr 16: 65.44 - 65.45 Mb

Chr 8: 107.43 - 107.44 Mb

Pubmed search

[1]

[2]

Carbonic anhydrase VII, also known as CA7, is a human gene.^[1]

Carbonic anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. The cytosolic protein encoded by this gene is predominantly expressed in the salivary glands. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms.^[1]

[edit] References

^ ^a ^b Entrez Gene: CA7 carbonic anhydrase VII.

[edit] Further reading

Sly WS, Hu PY (1995). "Human carbonic anhydrases and carbonic anhydrase deficiencies.". Annu. Rev. Biochem. 64: 375-401. doi:10.1146/annurev.bi.64.070195.002111. PMID 7574487.
Breton S (2002). "The cellular physiology of carbonic anhydrases.". JOP 2 (4 Suppl): 159-64. PMID 11875253.
Rivera C, Voipio J, Kaila K (2005). "Two developmental switches in GABAergic signalling: the K+-Cl- cotransporter KCC2 and carbonic anhydrase CAVII.". J. Physiol. (Lond.) 562 (Pt 1): 27-36. doi:10.1113/jphysiol.2004.077495. PMID 15528236.
Montgomery JC, Venta PJ, Eddy RL, et al. (1992). "Characterization of the human gene for a newly discovered carbonic anhydrase, CA VII, and its localization to chromosome 16.". Genomics 11 (4): 835-48. PMID 1783392.
Loftus BJ, Kim UJ, Sneddon VP, et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.". Genomics 60 (3): 295-308. doi:10.1006/geno.1999.5927. PMID 10493829.
Chagnon P, Michaud J, Mitchell G, et al. (2003). "A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis.". Am. J. Hum. Genet. 71 (6): 1443-9. PMID 12417987.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Vullo D, Voipio J, Innocenti A, et al. (2005). "Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.". Bioorg. Med. Chem. Lett. 15 (4): 971-6. doi:10.1016/j.bmcl.2004.12.052. PMID 15686895.