ARL3

From Wikipedia, the free encyclopedia

ADP-ribosylation factor-like 3

PDB rendering based on 1fzq.

Available structures: 1fzq

Identifiers

Symbol(s)

ARL3; ARFL3

External IDs

OMIM: 604695 MGI: 1929699 HomoloGene: 48276

Gene ontology
Molecular Function:	• nucleotide binding • signal transducer activity • GTP binding
Cellular Component:	• intracellular
Biological Process:	• G-protein coupled receptor protein signaling pathway • small GTPase mediated signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004311 (mRNA)
NP_004302 (protein)

NM_019718 (mRNA)
NP_062692 (protein)

Location

Chr 10: 104.42 - 104.46 Mb

Chr 19: 46.58 - 46.61 Mb

Pubmed search

[1]

[2]

ADP-ribosylation factor-like 3, also known as ARL3, is a human gene.^[1]

ADP-ribosylation factor-like 3 is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL3 binds guanine nucleotides but lacks ADP-ribosylation factor activity.^[1]

[edit] References

^ ^a ^b Entrez Gene: ARL3 ADP-ribosylation factor-like 3.

[edit] Further reading

Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.". Nature 377 (6547 Suppl): 3–174. PMID 7566098.
Cavenagh MM, Breiner M, Schurmann A, et al. (1994). "ADP-ribosylation factor (ARF)-like 3, a new member of the ARF family of GTP-binding proteins cloned from human and rat tissues.". J. Biol. Chem. 269 (29): 18937–42. PMID 8034651.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.
Kim HS (1999). "Assignment of the human ADP-ribosylation factor-like 3 (ARL3) gene to chromosome 10 band q23.3 by radiation hybrid mapping.". Cytogenet. Cell Genet. 83 (3-4): 246. PMID 10072593.
Linari M, Hanzal-Bayer M, Becker J (1999). "The delta subunit of rod specific cyclic GMP phosphodiesterase, PDE delta, interacts with the Arf-like protein Arl3 in a GTP specific manner.". FEBS Lett. 458 (1): 55–9. PMID 10518933.
Hillig RC, Hanzal-Bayer M, Linari M, et al. (2001). "Structural and biochemical properties show ARL3-GDP as a distinct GTP binding protein.". Structure 8 (12): 1239–45. PMID 11188688.
Van Valkenburgh H, Shern JF, Sharer JD, et al. (2001). "ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins.". J. Biol. Chem. 276 (25): 22826–37. doi:10.1074/jbc.M102359200. PMID 11303027.
Bartolini F, Bhamidipati A, Thomas S, et al. (2002). "Functional overlap between retinitis pigmentosa 2 protein and the tubulin-specific chaperone cofactor C.". J. Biol. Chem. 277 (17): 14629–34. doi:10.1074/jbc.M200128200. PMID 11847227.
Hanzal-Bayer M, Renault L, Roversi P, et al. (2002). "The complex of Arl2-GTP and PDE delta: from structure to function.". EMBO J. 21 (9): 2095–106. doi:10.1093/emboj/21.9.2095. PMID 11980706.
Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts.". Mol. Vis. 8: 196–204. PMID 12107411.
Grayson C, Bartolini F, Chapple JP, et al. (2003). "Localization in the human retina of the X-linked retinitis pigmentosa protein RP2, its homologue cofactor C and the RP2 interacting protein Arl3.". Hum. Mol. Genet. 11 (24): 3065–74. PMID 12417528.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Kühnel K, Veltel S, Schlichting I, Wittinghofer A (2006). "Crystal structure of the human retinitis pigmentosa 2 protein and its interaction with Arl3.". Structure 14 (2): 367–78. doi:10.1016/j.str.2005.11.008. PMID 16472755.
Zhou C, Cunningham L, Marcus AI, et al. (2006). "Arl2 and Arl3 regulate different microtubule-dependent processes.". Mol. Biol. Cell 17 (5): 2476–87. doi:10.1091/mbc.E05-10-0929. PMID 16525022.