ARFGEF1

From Wikipedia, the free encyclopedia

ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)

Identifiers

ARFGEF1; P200; ARFGEP1; BIG1; D730028O18Rik; DKFZP434L057

External IDs

OMIM: 604141 MGI: 2442988 HomoloGene: 4687

Gene ontology
Molecular Function:	• ARF guanyl-nucleotide exchange factor activity • ARF GTPase activator activity • myosin binding
Cellular Component:	• intracellular
Biological Process:	• exocytosis • regulation of ARF protein signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_006421 (mRNA)
NP_006412 (protein)

XM_905685 (mRNA)
XP_910778 (protein)

Location

Chr 8: 68.27 - 68.42 Mb

Chr 1: 10.12 - 10.22 Mb

Pubmed search

[1]

[2]

ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited), also known as ARFGEF1, is a human gene.^[1]

ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for the guanine-nucleotide exchange activity and also the brefeldin A inhibition.^[1]

[edit] References

^ ^a ^b Entrez Gene: ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited).

[edit] Further reading

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Morinaga N, Tsai SC, Moss J, Vaughan M (1996). "Isolation of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP ribosylation factor (ARF) 1 and ARF3 that contains a Sec7-like domain.". Proc. Natl. Acad. Sci. U.S.A. 93 (23): 12856–60. PMID 8917509.
Togawa A, Morinaga N, Ogasawara M, et al. (1999). "Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors.". J. Biol. Chem. 274 (18): 12308–15. PMID 10212200.
Mansour SJ, Skaug J, Zhao XH, et al. (1999). "p200 ARF-GEP1: a Golgi-localized guanine nucleotide exchange protein whose Sec7 domain is targeted by the drug brefeldin A.". Proc. Natl. Acad. Sci. U.S.A. 96 (14): 7968–73. PMID 10393931.
Yamaji R, Adamik R, Takeda K, et al. (2000). "Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex.". Proc. Natl. Acad. Sci. U.S.A. 97 (6): 2567–72. PMID 10716990.
Kamei Y, Takeda Y, Teramoto K, et al. (2001). "Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members.". Genomics 69 (1): 113–9. doi:10.1006/geno.2000.6310. PMID 11013081.
Padilla PI, Chang MJ, Pacheco-Rodriguez G, et al. (2003). "Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506.". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2322–7. doi:10.1073/pnas.2628047100. PMID 12606707.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Padilla PI, Pacheco-Rodriguez G, Moss J, Vaughan M (2004). "Nuclear localization and molecular partners of BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors.". Proc. Natl. Acad. Sci. U.S.A. 101 (9): 2752–7. doi:10.1073/pnas.0307345101. PMID 14973189.
Saeki N, Tokuo H, Ikebe M (2005). "BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein activity.". J. Biol. Chem. 280 (11): 10128–34. doi:10.1074/jbc.M413415200. PMID 15644318.
Citterio C, Jones HD, Pacheco-Rodriguez G, et al. (2006). "Effect of protein kinase A on accumulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) in HepG2 cell nuclei.". Proc. Natl. Acad. Sci. U.S.A. 103 (8): 2683–8. doi:10.1073/pnas.0510571103. PMID 16467138.
Belov GA, Altan-Bonnet N, Kovtunovych G, et al. (2007). "Hijacking components of the cellular secretory pathway for replication of poliovirus RNA.". J. Virol. 81 (2): 558–67. doi:10.1128/JVI.01820-06. PMID 17079330.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Shen X, Hong MS, Moss J, Vaughan M (2007). "BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein, is required for correct glycosylation and function of integrin beta1.". Proc. Natl. Acad. Sci. U.S.A. 104 (4): 1230–5. doi:10.1073/pnas.0610535104. PMID 17227842.
Kuroda F, Moss J, Vaughan M (2007). "Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma.". Proc. Natl. Acad. Sci. U.S.A. 104 (9): 3201–6. doi:10.1073/pnas.0611696104. PMID 17360629.