Amorolfine
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Amorolfine
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| Systematic (IUPAC) name | |
| (2S,6R)-2,6-dimethyl-4-[2-methyl-3-[4- (2-methylbutan-2-yl)phenyl]propyl]morpholine |
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| Identifiers | |
| CAS number | |
| ATC code | D01 |
| PubChem | |
| Chemical data | |
| Formula | C21H35N |
| Mol. mass | 317.509 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
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| Legal status | |
| Routes | ? |
Amorolfine (or amorolfin), is an allylamine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in the fungal cytoplasmic cell membranes.
Marketed as Curanail, Loceryl, Locetar, and Odenil, Amorolfine is commonly available in the form of a Nail Lacquer, containing 5% Amorolfine as the active ingredient. It is currently available over the counter in the UK, having recently been re-classified from prescription-only status.
Amorolfine exhibits a broad spectrum of action, meaning that it kills a wide variety of different fungi, and when used as directed can actually cure the infection for a majority of sufferers.
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