AIF1

From Wikipedia, the free encyclopedia

Allograft inflammatory factor 1

PDB rendering based on 2d58.

Available structures: 2d58, 2g2b

Identifiers

Symbol(s)

AIF1; AIF-1; IBA1; IRT-1

External IDs

OMIM: 601833 MGI: 1343098 HomoloGene: 1226

Gene ontology
Molecular Function:	• molecular_function • calcium ion binding
Cellular Component:	• cellular_component • nucleus
Biological Process:	• response to stress • inflammatory response • cell cycle arrest • biological_process • negative regulation of cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001623 (mRNA)
NP_001614 (protein)

NM_019467 (mRNA)
NP_062340 (protein)

Location

Chr 6: 31.69 - 31.69 Mb

Chr 17: 34.78 - 34.78 Mb

Pubmed search

[1]

[2]

Allograft inflammatory factor 1, also known as AIF1, is a human gene.^[1]

This gene is induced by cytokines and interferon. Its protein product is thought to be involved in negative regulation of growth of vascular smooth muscle cells, which contributes to the anti-inflammatory response to vessel wall trauma. The gene expresses three transcripts.^[1]

[edit] References

^ ^a ^b Entrez Gene: AIF1 allograft inflammatory factor 1.

[edit] Further reading

Deininger MH, Meyermann R, Schluesener HJ (2002). "The allograft inflammatory factor-1 family of proteins.". FEBS Lett. 514 (2-3): 115-21. PMID 11943136.
Jia J, Zhao YF, Zhao JH (2007). "Potential roles of allograft inflammatory factor-1 in the pathogenesis of hemangiomas.". Med. Hypotheses 68 (2): 288-90. doi:10.1016/j.mehy.2006.07.029. PMID 17010532.
Utans U, Arceci RJ, Yamashita Y, Russell ME (1995). "Cloning and characterization of allograft inflammatory factor-1: a novel macrophage factor identified in rat cardiac allografts with chronic rejection.". J. Clin. Invest. 95 (6): 2954-62. PMID 7769138.
Iris FJ, Bougueleret L, Prieur S, et al. (1993). "Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment.". Nat. Genet. 3 (2): 137-45. doi:10.1038/ng0293-137. PMID 8499947.
Utans U, Quist WC, McManus BM, et al. (1996). "Allograft inflammatory factory-1. A cytokine-responsive macrophage molecule expressed in transplanted human hearts.". Transplantation 61 (9): 1387-92. PMID 8629302.
Autieri MV (1996). "cDNA cloning of human allograft inflammatory factor-1: tissue distribution, cytokine induction, and mRNA expression in injured rat carotid arteries.". Biochem. Biophys. Res. Commun. 228 (1): 29-37. doi:10.1006/bbrc.1996.1612. PMID 8912632.
Autieri MV, Agrawal N (1998). "IRT-1, a novel interferon-gamma-responsive transcript encoding a growth-suppressing basic leucine zipper protein.". J. Biol. Chem. 273 (24): 14731-7. PMID 9614071.
Neville MJ, Campbell RD (1999). "A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC.". J. Immunol. 162 (8): 4745-54. PMID 10202016.
Sasaki Y, Ohsawa K, Kanazawa H, et al. (2001). "Iba1 is an actin-cross-linking protein in macrophages/microglia.". Biochem. Biophys. Res. Commun. 286 (2): 292-7. doi:10.1006/bbrc.2001.5388. PMID 11500035.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Autieri MV, Kelemen SE, Wendt KW (2003). "AIF-1 is an actin-polymerizing and Rac1-activating protein that promotes vascular smooth muscle cell migration.". Circ. Res. 92 (10): 1107-14. doi:10.1161/01.RES.0000074000.03562.CC. PMID 12714565.
Deininger MH, Weinschenk T, Meyermann R, Schluesener HJ (2003). "The allograft inflammatory factor-1 in Creutzfeldt-Jakob disease brains.". Neuropathol. Appl. Neurobiol. 29 (4): 389-99. PMID 12887599.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805-11. doi:10.1038/nature02055. PMID 14574404.
Xie T, Rowen L, Aguado B, et al. (2004). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.". Genome Res. 13 (12): 2621-36. doi:10.1101/gr.1736803. PMID 14656967.
Ohsawa K, Imai Y, Sasaki Y, Kohsaka S (2004). "Microglia/macrophage-specific protein Iba1 binds to fimbrin and enhances its actin-bundling activity.". J. Neurochem. 88 (4): 844-56. PMID 14756805.
Chen X, Kelemen SE, Autieri MV (2005). "AIF-1 expression modulates proliferation of human vascular smooth muscle cells by autocrine expression of G-CSF.". Arterioscler. Thromb. Vasc. Biol. 24 (7): 1217-22. doi:10.1161/01.ATV.0000130024.50058.de. PMID 15117732.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Arvanitis DA, Flouris GA, Spandidos DA (2005). "Genomic rearrangements on VCAM1, SELE, APEG1and AIF1 loci in atherosclerosis.". J. Cell. Mol. Med. 9 (1): 153-9. PMID 15784173.
Autieri MV, Chen X (2005). "The ability of AIF-1 to activate human vascular smooth muscle cells is lost by mutations in the EF-hand calcium-binding region.". Exp. Cell Res. 307 (1): 204-11. doi:10.1016/j.yexcr.2005.03.002. PMID 15922740.