3-deoxy-D-manno-octulosonate aldolase

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In enzymology, a 3-deoxy-D-manno-octulosonate aldolase (EC 4.1.2.23) is an enzyme that catalyzes the chemical reaction

3-deoxy-D-manno-octulosonate pyruvate + D-arabinose

Hence, this enzyme has one substrate, 3-deoxy-D-manno-octulosonate, and two products, pyruvate and D-arabinose.

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 3-deoxy-D-manno-octulosonate D-arabinose-lyase (pyruvate-forming). Other names in common use include 2-keto-3-deoxyoctonate aldolase, KDOaldolase, 3-deoxyoctulosonic aldolase, 2-keto-3-deoxyoctonic aldolase, 3-deoxy-D-manno-octulosonic aldolase, and 3-deoxy-D-manno-octulosonate D-arabinose-lyase.

[edit] References

• IUBMB entry for 4.1.2.23
• BRENDA references for 4.1.2.23 (Recommended.)
• PubMed references for 4.1.2.23
• PubMed Central references for 4.1.2.23
• Google Scholar references for 4.1.2.23
• Ghalambor MA, Heath EC (1966). "The biosynthesis of cell wall lipopolysaccharide in Escherichia coli. V. Purification and properties of 3-deoxy-D-manno-octulosonate aldolase". J. Biol. Chem. 241: 3222–7. PMID 5912115. 

[edit] External links

The CAS registry number for this enzyme class is 9026-95-3.

• IUBMB entry for 4.1.2.23

• KEGG entry for 4.1.2.23

• BRENDA entry for 4.1.2.23

• NiceZyme view of 4.1.2.23

• EC2PDB: PDB structures for 4.1.2.23

• PRIAM entry for 4.1.2.23

• PUMA2 entry for 4.1.2.23

• IntEnz: Integrated Enzyme entry for 4.1.2.23

• MetaCyc entry for 4.1.2.23

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047439: 3-deoxy-D-manno-octulosonate aldolase

• AMIGO entry for GO code 0047439: 3-deoxy-D-manno-octulosonate aldolase