Stem cell factor

From Wikipedia, the free encyclopedia

KIT ligand

PDB rendering based on 1exz.

Available structures: 1exz, 1scf

Identifiers

Symbol(s)

KITLG; SF; DKFZp686F2250; KL-1; Kitl; MGF; SCF

External IDs

OMIM: 184745 MGI: 96974 HomoloGene: 692

Gene ontology
Molecular Function:	• stem cell factor receptor binding • protein binding • growth factor activity
Cellular Component:	• extracellular space • plasma membrane • membrane • integral to membrane
Biological Process:	• cell adhesion • signal transduction • cell proliferation • organ morphogenesis • hemopoiesis • positive regulation of peptidyl-tyrosine phosphorylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000899 (mRNA)
NP_000890 (protein)

NM_013598 (mRNA)
NP_038626 (protein)

Location

Chr 12: 87.41 - 87.5 Mb

Chr 10: 99.45 - 99.52 Mb

Pubmed search

[1]

[2]

Stem cell factor (SCF), otherwise known as KIT ligand or Steel factor^[1],is a cytokine which binds CD117 (c-Kit). SCF is also known as "steel factor" or "c-kit ligand". SCF exists in two forms, cell surface bound SCF and soluble (or free) SCF. Soluble SCF is produced by the cleavage of surface bound SCF by metalloproteases.

SCF is a growth factor important for the survival, proliferation, and differentiation of hematopoietic stem cells and other hematopoietic progenitor cells. One of its roles is to change the BFU-E(burst-forming unit-erythroid) cells, which are the earliest erythrocyte precursors in the erythrocytic series, into the CFU-E (colony-forming unit-erythroid)^[2]. SCF, along with bFGF (basic fibroblast growth factor) and LIF (lymphocyte inhibitory factor), prevents spontaneous differentiation of primitive embryonic stem cells in cell culture^[1].

Ancestim is a recombinant form of SCF.^[3]

[edit] References

^ ^a ^b Freshney, Ian R. Culture of Animal Cells: A manual of basic technique. John Wiley & Sons, Inc., Hoboken, New Jersey. ISBN 13 978-0-471-45329-1
^ u_02/12836993 at Dorland's Medical Dictionary
^ da Silva MG, Pimentel P, Carvalhais A, et al (2004). "Ancestim (recombinant human stem cell factor, SCF) in association with filgrastim does not enhance chemotherapy and/or growth factor-induced peripheral blood progenitor cell (PBPC) mobilization in patients with a prior insufficient PBPC collection". Bone Marrow Transplant. 34 (8): 683–91. doi:10.1038/sj.bmt.1704602. PMID 15322567.

[edit] Further reading

Broudy VC (1997). "Stem cell factor and hematopoiesis.". Blood 90 (4): 1345–64. PMID 9269751.
Andrews RG, Briddell RA, Appelbaum FR, McNiece IK (1999). "Stimulation of hematopoiesis in vivo by stem cell factor.". Curr. Opin. Hematol. 1 (3): 187–96. PMID 9371281.
Wehrle-Haller B (2004). "The role of Kit-ligand in melanocyte development and epidermal homeostasis.". Pigment Cell Res. 16 (3): 287–96. PMID 12753403.
Rönnstrand L (2004). "Signal transduction via the stem cell factor receptor/c-Kit.". Cell. Mol. Life Sci. 61 (19-20): 2535–48. doi:10.1007/s00018-004-4189-6. PMID 15526160.
Mroczko B, Szmitkowski M (2005). "Hematopoietic cytokines as tumor markers.". Clin. Chem. Lab. Med. 42 (12): 1347–54. doi:10.1515/CCLM.2004.253. PMID 15576295.
Lev S, Yarden Y, Givol D (1992). "A recombinant ectodomain of the receptor for the stem cell factor (SCF) retains ligand-induced receptor dimerization and antagonizes SCF-stimulated cellular responses.". J. Biol. Chem. 267 (15): 10866–73. PMID 1375232.
Huang EJ, Nocka KH, Buck J, Besmer P (1992). "Differential expression and processing of two cell associated forms of the kit-ligand: KL-1 and KL-2.". Mol. Biol. Cell 3 (3): 349–62. PMID 1378327.
Toyota M, Hinoda Y, Itoh F, et al. (1992). "Expression of two types of kit ligand mRNAs in human tumor cells.". Int. J. Hematol. 55 (3): 301–4. PMID 1379846.
Lu HS, Clogston CL, Wypych J, et al. (1992). "Post-translational processing of membrane-associated recombinant human stem cell factor expressed in Chinese hamster ovary cells.". Arch. Biochem. Biophys. 298 (1): 150–8. PMID 1381905.
Sharkey A, Jones DS, Brown KD, Smith SK (1992). "Expression of messenger RNA for kit-ligand in human placenta: localization by in situ hybridization and identification of alternatively spliced variants.". Mol. Endocrinol. 6 (8): 1235–41. PMID 1383693.
Mathew S, Murty VV, Hunziker W, Chaganti RS (1992). "Subregional mapping of 13 single-copy genes on the long arm of chromosome 12 by fluorescence in situ hybridization.". Genomics 14 (3): 775–9. PMID 1427906.
Geissler EN, Liao M, Brook JD, et al. (1991). "Stem cell factor (SCF), a novel hematopoietic growth factor and ligand for c-kit tyrosine kinase receptor, maps on human chromosome 12 between 12q14.3 and 12qter.". Somat. Cell Mol. Genet. 17 (2): 207–14. PMID 1707188.
Anderson DM, Williams DE, Tushinski R, et al. (1992). "Alternate splicing of mRNAs encoding human mast cell growth factor and localization of the gene to chromosome 12q22-q24.". Cell Growth Differ. 2 (8): 373–8. PMID 1724381.
Martin FH, Suggs SV, Langley KE, et al. (1990). "Primary structure and functional expression of rat and human stem cell factor DNAs.". Cell 63 (1): 203–11. PMID 2208279.
Ramenghi U, Ruggieri L, Dianzani I, et al. (1995). "Human peripheral blood granulocytes and myeloid leukemic cell lines express both transcripts encoding for stem cell factor.". Stem Cells 12 (5): 521–6. PMID 7528592.
Saito S, Enomoto M, Sakakura S, et al. (1995). "Localization of stem cell factor (SCF) and c-kit mRNA in human placental tissue and biological effects of SCF on DNA synthesis in primary cultured cytotrophoblasts.". Biochem. Biophys. Res. Commun. 205 (3): 1762–9. doi:10.1006/bbrc.1994.2873. PMID 7529021.
Laitinen M, Rutanen EM, Ritvos O (1995). "Expression of c-kit ligand messenger ribonucleic acids in human ovaries and regulation of their steady state levels by gonadotropins in cultured granulosa-luteal cells.". Endocrinology 136 (10): 4407–14. PMID 7545103.
Blechman JM, Lev S, Brizzi MF, et al. (1993). "Soluble c-kit proteins and antireceptor monoclonal antibodies confine the binding site of the stem cell factor.". J. Biol. Chem. 268 (6): 4399–406. PMID 7680037.
Lu HS, Jones MD, Shieh JH, et al. (1996). "Isolation and characterization of a disulfide-linked human stem cell factor dimer. Biochemical, biophysical, and biological comparison to the noncovalently held dimer.". J. Biol. Chem. 271 (19): 11309–16. PMID 8626683.
Vanhaesebroeck B, Welham MJ, Kotani K, et al. (1997). "P110delta, a novel phosphoinositide 3-kinase in leukocytes.". Proc. Natl. Acad. Sci. U.S.A. 94 (9): 4330–5. PMID 9113989.

[edit] External links

MeSH Stem+cell+factor
http://www.genome.jp/dbget-bin/show_pathway?hsa04640+4254 - KEGG pathway: Hematopoietic cell lineage

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v • d • e Cell signaling: cytokines

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Stem cell factor

From Wikipedia, the free encyclopedia

[edit] References

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