SERPINB13

From Wikipedia, the free encyclopedia

Serpin peptidase inhibitor, clade B (ovalbumin), member 13

Identifiers

SERPINB13; HUR7; MGC126870; PI13; headpin

External IDs

OMIM: 604445 MGI: 3042250 HomoloGene: 22718

Gene ontology
Molecular Function:	• serine-type endopeptidase inhibitor activity
Cellular Component:	• cellular_component
Biological Process:	• response to UV • regulation of proteolysis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_012397 (mRNA)
NP_036529 (protein)

NM_172852 (mRNA)
NP_766440 (protein)

Location

Chr 18: 59.41 - 59.42 Mb

Chr 1: 108.81 - 108.83 Mb

Pubmed search

[1]

[2]

Serpin peptidase inhibitor, clade B (ovalbumin), member 13, also known as SERPINB13, is a human gene.^[1]

1 See also
2 References
3 Further reading
4 External links

[edit] See also

Serpin

[edit] References

^ Entrez Gene: SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13.

[edit] Further reading

Abts HF, Breuhahn K, Michel G, et al. (1997). "Analysis of UVB-modulated gene expression in human keratinocytes by mRNA differential display polymerase chain reaction.". Photochem. Photobiol. 66 (3): 363–7. PMID 9297979.
Abts HF, Welss T, Mirmohammadsadegh A, et al. (1999). "Cloning and characterization of hurpin (protease inhibitor 13): A new skin-specific, UV-repressible serine proteinase inhibitor of the ovalbumin serpin family.". J. Mol. Biol. 293 (1): 29–39. doi:10.1006/jmbi.1999.3159. PMID 10512713.
Spring P, Nakashima T, Frederick M, et al. (1999). "Identification and cDNA cloning of headpin, a novel differentially expressed serpin that maps to chromosome 18q.". Biochem. Biophys. Res. Commun. 264 (1): 299–304. doi:10.1006/bbrc.1999.1453. PMID 10527881.
Nakashima T, Pak SC, Silverman GA, et al. (2000). "Genomic cloning, mapping, structure and promoter analysis of HEADPIN, a serpin which is down-regulated in head and neck cancer cells.". Biochim. Biophys. Acta 1492 (2-3): 441–6. PMID 11004515.
Abts HF, Welss T, Scheuring S, et al. (2001). "Sequence, organization, chromosomal localization, and alternative splicing of the human serine protease inhibitor gene hurpin (PI13) which is upregulated in psoriasis.". DNA Cell Biol. 20 (3): 123–31. doi:10.1089/104454901300068924. PMID 11313015.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Jayakumar A, Kang Y, Frederick MJ, et al. (2003). "Inhibition of the cysteine proteinases cathepsins K and L by the serpin headpin (SERPINB13): a kinetic analysis.". Arch. Biochem. Biophys. 409 (2): 367–74. PMID 12504904.
Welss T, Sun J, Irving JA, et al. (2003). "Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet-induced apoptosis.". Biochemistry 42 (24): 7381–9. doi:10.1021/bi027307q. PMID 12809493.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Moussali H, Bylaite M, Welss T, et al. (2005). "Expression of hurpin, a serine proteinase inhibitor, in normal and pathological skin: overexpression and redistribution in psoriasis and cutaneous carcinomas.". Exp. Dermatol. 14 (6): 420–8. doi:10.1111/j.0906-6705.2005.00300.x. PMID 15885077.
Shellenberger TD, Mazumdar A, Henderson Y, et al. (2006). "Headpin: a serpin with endogenous and exogenous suppression of angiogenesis.". Cancer Res. 65 (24): 11501–9. doi:10.1158/0008-5472.CAN-05-2262. PMID 16357159.
Bylaite M, Moussali H, Marciukaitiene I, et al. (2006). "Expression of cathepsin L and its inhibitor hurpin in inflammatory and neoplastic skin diseases.". Exp. Dermatol. 15 (2): 110–8. doi:10.1111/j.1600-0625.2005.00389.x. PMID 16433682.

[edit] External links

MeSH SERPINB13+protein,+human

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v • d • e Serpins

inhibitory	Alpha 1-antichymotrypsin · Alpha 1-antitrypsin · Alpha 2-antiplasmin · Antithrombin · C1-inhibitor · Heparin cofactor II · Protein C inhibitor · Plasminogen activator inhibitor-1 · Plasminogen activator inhibitor-2 · Protein Z-related protease inhibitor · SERPINA4 · SERPINA6 · SERPINB1 · SERPINB3 · SERPINB4 · SERPINB6 · SERPINB7 · SERPINB8 · SERPINB9 · SERPINB13 · SERPINE2 · SERPINF2

Cross class inhibitory	MENT · SCCA-1 · crmA

noninhibitory	Heat shock protein 47 · Maspin · Ovalbumin · SERPINF1 · Thyroxine-binding globulin · Transcortin · SERPINF1