Aspergillus fumigatus
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 Aspergillus fumigatus
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| Aspergillus fumigatus Fresenius 1863 |
Aspergillus fumigatus is a fungus of the genus Aspergillus, and is one of the most common Aspergillus species to cause disease in immunocompromised individuals.
A. fumigatus has a stable haploid genome, with no known sexual cycle, and reproduces by forming conidiospores that are released into the environment. Capable of growth at 37°C (human body temperature), spores are common inhalation pollutants; typically, however, these are quickly eliminated by the immune system in healthy individuals.
When the fermentation broth of A. fumigatus was screened, a number of indolic alkaloids with anti-mitotic properties were discovered.[1] The compounds of interest have been of a class known as tryprostatins, with spirotryprostatin B being of special interest as an anti-cancer drug.
[edit] Genome
The genome sequences of three Aspergillus species—Aspergillus fumigatus, Aspergillus nidulans, and Aspergillus oryzae—were published in the journal Nature in December 2005.[2][3][4]
[edit] Gallery
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 Conidia phialoconidia of Aspergillus fumigatus |
 Colony in Petri dish |
 Aspergillus fumigatus isolated from woodland soil |
[edit] See also
[edit] References
- ^ Cui CB et al (1996). "Spirotryprostatin B, a novel mammalian cell cycle inhibitor produced by Aspergillus fumigatus". J. Antibiot. 49: 832-835. PMID 8823522.
- ^ Galagan JE et al (2005). "Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae". Nature 438 (7071): 1105-15. doi:. PMID 16372000.
- ^ Nierman WC et al (2005). "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus". Nature 438 (7071): 1151-6. doi:. PMID 16372009.
- ^ Machida M et al (2005). "Genome sequencing and analysis of Aspergillus oryzae". Nature 438 (7071): 1157-61. doi:. PMID 16372010.
[edit] External links
- The Aspergillus Trust A registered UK charity engaged in support of sufferers of aspergillus disease worldwide and research into cures
- The Fungal Research Trust
- Aspergillus info from DoctorFungus.org
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