Amoxapine
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Amoxapine
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| Systematic (IUPAC) name | |
| 2-Chloro-11-(1-piperazinyl)dibenz[b,f][1,4]oxazepine | |
| Identifiers | |
| CAS number | |
| ATC code | N06 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C17H16ClN3O |
| Mol. mass | 313.781 |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | Hepatic (cytochrome P450 system) |
| Half life | 8-10 hours (30 hours for major metabolites) |
| Excretion | Renal |
| Therapeutic considerations | |
| Pregnancy cat. |
C(US) |
| Legal status | |
| Routes | Oral |
Amoxapine (brand-names Asendin, Asendis, Defanyl, Demolox, Moxadil) is a tricyclic antidepressant of the dibenzoxazepine class. It is used in the treatment of depression, panic disorders and bipolar disorder.
Amoxapine is a strong reuptake inhibitor of norepinephrine and weak reuptake inhibitor of serotonin. One of its major metabolites, 7-hydroxyamoxapine, has a dopamine receptor blocking effect, making this drug a common cause of neuroleptic malignant syndrome. Amoxapine is also associated with acute extra pyramidal symptoms and tardive dyskinesia.
[edit] See also
[edit] References
- Mosby Year-Book, Inc. (1995). Physician's GenRx: The Complete Drug Reference (5th Ed.). Riverside, CT: Denniston Publishing Co.
- Palfai, T. & Jankiewicz, H. (1997). Drugs and Human Behavior (2nd Ed.). Madison, WI: Brown & Benchmark.
- Hedges, D. & Burchfield, C. (2006). Mind, Brain, and Drug: An Introduction to Psychopharmacology. Boston, MA: Pearson.
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