STAT5A

From Wikipedia, the free encyclopedia

Signal transducer and activator of transcription 5A

PDB rendering based on 1y1u.

Available structures: 1y1u

Identifiers

Symbol(s)

STAT5A; MGF; STAT5

External IDs

OMIM: 601511 MGI: 103036 HomoloGene: 20680

Gene ontology
Molecular Function:	• transcription factor activity • signal transducer activity • calcium ion binding • protein binding
Cellular Component:	• nucleus • cytoplasm
Biological Process:	• luteinization • natural killer cell differentiation • transcription • immune response • intracellular signaling cascade • JAK-STAT cascade • female pregnancy • lactation • positive regulation of cell proliferation • regulation of steroid metabolic process • cytokine and chemokine mediated signaling pathway • sequestering of lipid • regulation of cell adhesion • regulation of epithelial cell differentiation • mammary gland development • positive regulation of body size • positive regulation of activated T cell proliferation • T cell homeostasis • negative regulation of apoptosis • positive regulation of interleukin-2 biosynthetic process • positive regulation of B cell differentiation • negative regulation of erythrocyte differentiation • positive regulation of survival gene product activity • positive regulation of progression through mitotic cell cycle • positive regulation of transcription from RNA polymerase II promoter • development of secondary female sexual characteristics • development of secondary male sexual characteristics • positive regulation of inflammatory response

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003152 (mRNA)
NP_003143 (protein)

NM_011488 (mRNA)
NP_035618 (protein)

Location

Chr 17: 37.69 - 37.72 Mb

Chr 11: 100.68 - 100.7 Mb

Pubmed search

[1]

[2]

Signal transducer and activator of transcription 5A, also known as STAT5A, is a human gene.

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells.^[1]

[edit] See also

STAT5

[edit] References

^ Entrez Gene: STAT5A signal transducer and activator of transcription 5A.

[edit] Further reading

Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW (2002). "Signaling through the JAK/STAT pathway, recent advances and future challenges.". Gene 285 (1-2): 1–24. PMID 12039028.
Buitenhuis M, Coffer PJ, Koenderman L (2005). "Signal transducer and activator of transcription 5 (STAT5).". Int. J. Biochem. Cell Biol. 36 (11): 2120–4. doi:10.1016/j.biocel.2003.11.008. PMID 15313458.