Saccharopine dehydrogenase

saccharopine dehydrogenase (putative)
Identifiers
Symbol	SCCPDH
Entrez	51097
HUGO	24275
RefSeq	NM_016002
UniProt	Q8NBX0
Other data
Locus	Chr. 1 q44

Saccharopine dehydrogenase is an enzyme involved in the metabolism of lysine, via saccharopine.

It can be classified under EC 1.5.1.7, EC 1.5.1.8, EC 1.5.1.9, and EC 1.5.1.10.

[edit] Pathology

Deficiencies are associated with hyperlysinemia.

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v • d • e CH-NH oxidoreductases (EC 1.5)

1.5.1 - NAD or NADP acceptor	Dihydrofolate reductase - Saccharopine dehydrogenase - Methylenetetrahydrofolate reductase

1.5.3 - oxygen acceptor	Dihydrobenzophenanthridine oxidase - Sarcosine oxidase - Proline oxidase

1.5.5 - quinone acceptor	Electron-transferring-flavoprotein dehydrogenase

v • d • e

LYSINE→	Saccharopine dehydrogenase - Glutaryl-CoA dehydrogenase

LEUCINE→	Branched chain aminotransferase - Branched-chain alpha-keto acid dehydrogenase complex - Isovaleryl coenzyme A dehydrogenase - Methylcrotonyl-CoA carboxylase - Methylglutaconyl-CoA hydratase - 3-hydroxy-3-methylglutaryl-CoA lyase

TRYPTOPHAN→	Indoleamine 2,3-dioxygenase/Tryptophan 2,3-dioxygenase - Arylformamidase - Kynureninase - 3-hydroxyanthranilate oxidase - Aminocarboxymuconate-semialdehyde decarboxylase - Aminomuconate-semialdehyde dehydrogenase

PHENYLALANINE→tyrosine→	(see below)

glycine→serine→	Serine hydroxymethyltransferase - Serine dehydratase

alanine→	Alanine transaminase

cysteine→	D-cysteine desulfhydrase

threonine→	L-threonine dehydrogenase


HISTIDINE→	Histidine ammonia-lyase - Urocanate hydratase - Formiminotransferase cyclodeaminase

proline→	Proline oxidase - Pyrroline-5-carboxylate reductase - 1-Pyrroline-5-carboxylate dehydrogenase/ALDH4A1 - PYCR1

arginine→	Ornithine aminotransferase - Ornithine decarboxylase - Agmatinase

→alpha-ketoglutarate→TCA	Glutamate dehydrogenase


PHENYLALANINE→tyrosine→	Phenylalanine hydroxylase - Tyrosine aminotransferase - 4-Hydroxyphenylpyruvate dioxygenase - Homogentisate 1,2-dioxygenase - Fumarylacetoacetate hydrolase