POLE2

From Wikipedia, the free encyclopedia

Polymerase (DNA directed), epsilon 2 (p59 subunit)

Identifiers

External IDs

OMIM: 602670 MGI: 1197514 HomoloGene: 2015

Gene ontology
Molecular Function:	• DNA binding • epsilon DNA polymerase activity • transferase activity
Cellular Component:	• nucleus
Biological Process:	• DNA replication • DNA repair

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002692 (mRNA)
NP_002683 (protein)

NM_011133 (mRNA)
NP_035263 (protein)

Location

Chr 14: 49.18 - 49.22 Mb

Chr 12: 70.12 - 70.15 Mb

Pubmed search

[1]

[2]

Polymerase (DNA directed), epsilon 2 (p59 subunit), also known as POLE2, is a human gene.^[1]

[edit] References

^ Entrez Gene: POLE2 polymerase (DNA directed), epsilon 2 (p59 subunit).

[edit] Further reading

Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957-68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Post SM, Tomkinson AE, Lee EY (2003). "The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon.". Nucleic Acids Res. 31 (19): 5568-75. PMID 14500819.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Wada M, Miyazawa H, Wang RS, et al. (2002). "The second largest subunit of mouse DNA polymerase epsilon, DPE2, interacts with SAP18 and recruits the Sin3 co-repressor protein to DNA.". J. Biochem. 131 (3): 307-11. PMID 11872158.
Huang D, Jokela M, Tuusa J, et al. (2001). "E2F mediates induction of the Sp1-controlled promoter of the human DNA polymerase epsilon B-subunit gene POLE2.". Nucleic Acids Res. 29 (13): 2810-21. PMID 11433027.
Li Y, Pursell ZF, Linn S (2000). "Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon.". J. Biol. Chem. 275 (30): 23247-52. doi:10.1074/jbc.M002548200. PMID 10801849.
Jokela M, Mäkiniemi M, Lehtonen S, et al. (1998). "The small subunits of human and mouse DNA polymerase epsilon are homologous to the second largest subunit of the yeast Saccharomyces cerevisiae DNA polymerase epsilon.". Nucleic Acids Res. 26 (3): 730-4. PMID 9443964.
Li Y, Asahara H, Patel VS, et al. (1998). "Purification, cDNA cloning, and gene mapping of the small subunit of human DNA polymerase epsilon.". J. Biol. Chem. 272 (51): 32337-44. PMID 9405441.