POLA1

From Wikipedia, the free encyclopedia

Polymerase (DNA directed), alpha 1

PDB rendering based on 1k0p.

Available structures: 1k0p, 1k18, 1n5g

Identifiers

Symbol(s)

POLA1; DKFZp686K1672; POLA

External IDs

OMIM: 312040 MGI: 99660 HomoloGene: 6802

Gene ontology
Molecular Function:	• nucleotide binding • DNA binding • chromatin binding • alpha DNA polymerase activity • DNA primase activity • protein binding • sugar binding • zinc ion binding • 3'-5' exonuclease activity • transferase activity • metal ion binding
Cellular Component:	• chromatin • nucleus • nuclear envelope • nucleoplasm • alpha DNA polymerase:primase complex • nucleolus • nuclear matrix
Biological Process:	• S phase of mitotic cell cycle • DNA synthesis during DNA repair • DNA replication initiation • leading strand elongation • lagging strand elongation • double-strand break repair via nonhomologous end joining • cell proliferation • response to pH • response to virus

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_016937 (mRNA)
NP_058633 (protein)

NM_008892 (mRNA)
NP_032918 (protein)

Location

Chr X: 24.62 - 24.93 Mb

Chr X: 89.56 - 89.88 Mb

Pubmed search

[1]

[2]

Polymerase (DNA directed), alpha 1, also known as POLA1, is a human gene.^[1]

[edit] References

^ Entrez Gene: POLA1 polymerase (DNA directed), alpha 1.

[edit] Further reading

Pollok S, Stoepel J, Bauerschmidt C, et al. (2003). "Regulation of eukaryotic DNA replication at the initiation step.". Biochem. Soc. Trans. 31 (Pt 1): 266–9. doi:10.1042/. PMID 12546699.
Fisher PA, Korn D (1977). "DNA polymerase-alpha. Purification and structural characterization of the near homogeneous enzyme from human KB cells.". J. Biol. Chem. 252 (18): 6528–35. PMID 893425.
Dornreiter I, Erdile LF, Gilbert IU, et al. (1992). "Interaction of DNA polymerase alpha-primase with cellular replication protein A and SV40 T antigen.". EMBO J. 11 (2): 769–76. PMID 1311258.
Coverley D, Kenny MK, Lane DP, Wood RD (1992). "A role for the human single-stranded DNA binding protein HSSB/RPA in an early stage of nucleotide excision repair.". Nucleic Acids Res. 20 (15): 3873–80. PMID 1508673.
Popanda O, Thielmann HW (1992). "The function of DNA polymerases in DNA repair synthesis of ultraviolet-irradiated human fibroblasts.". Biochim. Biophys. Acta 1129 (2): 155–60. PMID 1730053.
Collins KL, Kelly TJ (1991). "Effects of T antigen and replication protein A on the initiation of DNA synthesis by DNA polymerase alpha-primase.". Mol. Cell. Biol. 11 (4): 2108–15. PMID 1848671.
Martelli AM, Cocco L, Manzoli FA (1991). "On the association of DNA polymerase alpha activity with the nuclear matrix in HeLa cells.". Cell Biol. Int. Rep. 15 (2): 131–40. PMID 1903085.
Pearson BE, Nasheuer HP, Wang TS (1991). "Human DNA polymerase alpha gene: sequences controlling expression in cycling and serum-stimulated cells.". Mol. Cell. Biol. 11 (4): 2081–95. PMID 2005899.
Matsumoto T, Eki T, Hurwitz J (1991). "Studies on the initiation and elongation reactions in the simian virus 40 DNA replication system.". Proc. Natl. Acad. Sci. U.S.A. 87 (24): 9712–6. PMID 2175912.
Hsi KL, Copeland WC, Wang TS (1991). "Human DNA polymerase alpha catalytic polypeptide binds ConA and RCA and contains a specific labile site in the N-terminus.". Nucleic Acids Res. 18 (21): 6231–7. PMID 2243771.
Wang TS, Pearson BE, Suomalainen HA, et al. (1985). "Assignment of the gene for human DNA polymerase alpha to the X chromosome.". Proc. Natl. Acad. Sci. U.S.A. 82 (16): 5270–4. PMID 2410918.
Knorre DG, Lavrik OI, Nevinsky GA (1988). "Protein-nucleic acid interaction in reactions catalyzed with DNA polymerases.". Biochimie 70 (5): 655–61. PMID 3139084.
Nishida C, Reinhard P, Linn S (1988). "DNA repair synthesis in human fibroblasts requires DNA polymerase delta.". J. Biol. Chem. 263 (1): 501–10. PMID 3335506.
Wong SW, Wahl AF, Yuan PM, et al. (1988). "Human DNA polymerase alpha gene expression is cell proliferation dependent and its primary structure is similar to both prokaryotic and eukaryotic replicative DNA polymerases.". EMBO J. 7 (1): 37–47. PMID 3359994.
Tsuda M, Masuyama M, Katsunuma T (1986). "Inhibition of human DNA polymerase alpha by alpha 1-antichymotrypsin.". Cancer Res. 46 (12 Pt 1): 6139–42. PMID 3490907.
Jackson DA, Cook PR (1987). "Different populations of DNA polymerase alpha in HeLa cells.". J. Mol. Biol. 192 (1): 77–86. PMID 3820307.
Miller MR, Seighman C, Ulrich RG (1986). "Inhibition of DNA replication and DNA polymerase alpha activity by monoclonal anti-(DNA polymerase alpha) immunoglobulin G and F(ab) fragments.". Biochemistry 24 (25): 7440–5. PMID 4084590.
Bensch KG, Tanaka S, Hu SZ, et al. (1982). "Intracellular localization of human DNA polymerase alpha with monoclonal antibodies.". J. Biol. Chem. 257 (14): 8391–6. PMID 7045121.
Tanaka S, Hu SZ, Wang TS, Korn D (1982). "Preparation and preliminary characterization of monoclonal antibodies against human DNA polymerase alpha.". J. Biol. Chem. 257 (14): 8386–90. PMID 7085672.
Eckert KA, Kunkel TA (1994). "Fidelity of DNA synthesis catalyzed by human DNA polymerase alpha and HIV-1 reverse transcriptase: effect of reaction pH.". Nucleic Acids Res. 21 (22): 5212–20. PMID 7504813.