Peramivir

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Peramivir
Systematic (IUPAC) name
(1S,2S,3S,4R)-3-[(1S)-1-Acetamido-2-ethyl-butyl] -4-(diaminomethylideneamino)-2-hydroxy-cyclopentane -1-carboxylic acid
Identifiers
CAS number	229614-55-5
ATC code	?
PubChem	151164
Chemical data
Formula	C₁₅H₂₈N₄O₄
Mol. mass	328.407 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Peramivir is an experimental antiviral drug being developed by Biocryst Pharmaceuticals to treat influenza. Peramivir is a neuraminidase inhibitor, acting as a transition-state analogue inhibitor of influenza neuraminidase and thereby preventing new viruses from emerging from infected cells. The development of peramivir is supported by the US Department of Health and Human Services as part of the government's effort to prepare for a flu pandemic.^[1]

The drug has had a long history. An oral formulation was abandoned by Johnson and Johnson due to poor bioavailability.^[2] BioCryst is now developing a injectable version, in partnership with Green Cross Pharmaceuticals in South Korea and with Shionogi Pharmaceuticals in Japan. The drug is in Phase II studies.^[3] ^[4]

[edit] Sources

v • d • e Antivirals, other than for HIV (primarily J05, also S01AD and D06BB)

Anti-herpesvirus (DNA, I)	guanine analogues (Aciclovir, Famciclovir, Ganciclovir, Penciclovir, Valaciclovir, Valganciclovir) • nucleoside analogues (Idoxuridine, Trifluridine, Vidarabine) • Cidofovir • Docosanol • Fomivirsen • Foscarnet • Tromantadine

HPV/MC (DNA, I)	Imiquimod • Podophyllotoxin

Hepatitis B (DNA, VII)	Adefovir • Clevudine • Interferon alfa-2b • Pegylated interferon alfa-2a • Entecavir • Lamivudine • Telbivudine • Tenofovir^†

Hepatitis C (RNA, IV)	Pegylated interferon alpha • Ribavirin • Taribavirin^† • Boceprevir^†

Picornavirus (RNA, IV)	Pleconaril^†

Anti-influenza agents (RNA, V)	Arbidol adamantane derivatives/M2 inhibitors (Amantadine, Rimantadine) neuraminidase inhibitors (Oseltamivir, Zanamivir, Peramivir^†)

HIV (Reverse, VI)	See HIV pharm

Other antiviral agents	general (Inosine, Interferon)

^†Undergoing clinical trials, not FDA approved.

v • d • e Influenza

Influenza	Research - Vaccine - Avian influenza - Treatment - Genome sequencing - Season

Influenza viruses	Orthomyxoviridae - Influenza A - Influenza B - Influenza C

Subtypes of Influenza A virus	H1N1 - H1N2 - H2N2 - H3N1 - H3N2 - H3N8 - H5N1 - H5N2 - H5N3 - H5N8 - H5N9 - H7N1 - H7N2 - H7N3 - H7N4 - H7N7 - H9N2 - H10N7

H5N1	Genetic structure - Transmission and infection - Global spread - Clinical Trials - Human mortality

Antiviral drugs	Arbidol - adamantane derivatives (Amantadine, Rimantadine) - neuraminidase inhibitors (Oseltamivir, Peramivir, Zanamivir) Experimental (Peramivir)

Influenza vaccines	FluMist - Fluzone

Influenza pandemics	Asian Flu - Hong Kong Flu - Spanish flu - Fujian flu - Pandemic Severity Index

Outbreaks of Avian influenza	Croatia (2005) - India (2006) - UK (2007) - West Bengal (2008)

Influenza in non-human mammals	Canine influenza - Equine influenza (2007 Australian outbreak) - Swine flu