PASK

From Wikipedia, the free encyclopedia

PAS domain containing serine/threonine kinase

PDB rendering based on 1ll8.

Available structures: 1ll8

Identifiers

Symbol(s)

PASK; DKFZP434O051; DKFZp686P2031; KIAA0135; PASKIN; STK37

External IDs

OMIM: 607505 MGI: 2155936 HomoloGene: 9038

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • signal transducer activity • ATP binding • transferase activity
Biological Process:	• regulation of transcription, DNA-dependent • protein amino acid phosphorylation • signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_015148 (mRNA)
NP_055963 (protein)

NM_080850 (mRNA)
NP_543126 (protein)

Location

Chr 2: 241.69 - 241.74 Mb

Chr 1: 95.14 - 95.17 Mb

Pubmed search

[1]

[2]

PAS domain containing serine/threonine kinase, also known as PASK, is a human gene.^[1]

PAS domains regulate the function of many intracellular signaling pathways in response to both extrinsic and intrinsic stimuli. PASK is an evolutionarily conserved protein present in yeast, flies, and mammals.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: PASK PAS domain containing serine/threonine kinase.

[edit] Further reading

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. PMID 12168954.
Nagase T, Seki N, Tanaka A, et al. (1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 2 (4): 167–74, 199–210. PMID 8590280.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.
Ceulemans H, Van Eynde A, Pérez-Callejón E, et al. (1999). "Structure and splice products of the human gene encoding sds22, a putative mitotic regulator of protein phosphatase-1.". Eur. J. Biochem. 262 (1): 36–42. PMID 10231361.
Rutter J, Michnoff CH, Harper SM, et al. (2001). "PAS kinase: an evolutionarily conserved PAS domain-regulated serine/threonine kinase.". Proc. Natl. Acad. Sci. U.S.A. 98 (16): 8991–6. doi:10.1073/pnas.161284798. PMID 11459942.
Hofer T, Spielmann P, Stengel P, et al. (2001). "Mammalian PASKIN, a PAS-serine/threonine kinase related to bacterial oxygen sensors.". Biochem. Biophys. Res. Commun. 288 (4): 757–64. doi:10.1006/bbrc.2001.5840. PMID 11688972.
Amezcua CA, Harper SM, Rutter J, Gardner KH (2003). "Structure and interactions of PAS kinase N-terminal PAS domain: model for intramolecular kinase regulation.". Structure 10 (10): 1349–61. PMID 12377121.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
da Silva Xavier G, Rutter J, Rutter GA (2004). "Involvement of Per-Arnt-Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucose.". Proc. Natl. Acad. Sci. U.S.A. 101 (22): 8319–24. doi:10.1073/pnas.0307737101. PMID 15148392.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
Eckhardt K, Troger J, Reissmann J, et al. (2007). "Male germ cell expression of the PAS domain kinase PASKIN and its novel target eukaryotic translation elongation factor eEF1A1.". Cell. Physiol. Biochem. 20 (1-4): 227–40. doi:10.1159/000104169. PMID 17595531.