p57 (gene)

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It has been suggested that this article or section be merged with Cyclin-dependent kinase inhibitor 1C. (Discuss)

p57 or p57KIP2 is a tumor suppressor human gene on chromosome 11 (11p15) and belongs to the cip/kip gene family. It encodes a cell cycle inhibitor that binds to G1 cyclin-CDK complexes. ^[1] Thus p57KIP2 causes arrest of the cell cycle in G1 phase. A mutation of this gene may lead to loss of control over the cell cycle leading to uncontrolled cellular proliferation. p57KIP2 has been associated with Beckwith-Wiedemann syndrome (BWS) which is characterized by increased risk of tumor formation in childhood. ^[2]

[edit] References

^ p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene. GENES & DEVELOPMENT 9:650-662, 1995. ISSN 0890-9369.
^ New p57KIP2 mutations in Beckwith-Wiedemann syndrome Human Genetics, Vol 100, Num 5-6 / Sept 1997.

v • d • e Cell cycle proteins

Cyclin	A - B - D - E

Cyclin-dependent kinase	2 - 3 - 4 - 5 - 6 - 7 - 8 - 9 - 10 - CDK-activating kinase

Cyclin-dependent kinase inhibitor protein	p14arf/p16INK4a - p21 - p27 - p57

Other	Cdc2 - Cdc25 - Cdc42 - Cellular apoptosis susceptibility protein - E2F - Maturation promoting factor - Wee

v • d • e Tumor suppressor genes/proteins

APC - BRCA1 - BRCA2 - CHEK2 - Neurofibromin 1 - Maspin - Neurofibromin 2/Merlin - p14arf - p16 - p21 - p27 - p53 - p57 - p73 - pRb - PTEN - SDHB - SDHD - VHL