Talk:Osteogenesis imperfecta

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To-do list for Osteogenesis imperfecta:	edit · history · watch · refresh
Strike through when completed Unlink section headings per WP:MoS Inline references Change external references to link to references section Edit section on Bisphosphonates per Talk page Additional sections: See also Signs and symptoms Causes Pathophysiology Diagnosis Prognosis Prevention/Screening Epidemiology Social impact See WP:MEDMOS for suggestions on layout and style

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This article must adhere to the policy on biographies of living persons. Controversial material about living persons that is unsourced or poorly sourced must be removed immediately, especially if potentially libellous. If such material is repeatedly inserted or if there are other concerns relative to this policy, report it on the living persons biographies noticeboard.

I have OI, and I'm generally good with that. I hope my edits are not biased because of that though. I think all I added was history of research, I hope I didn't copy that medical site too much, and the name Michael J. Anderson. To be honest I didn't know he was OI and I was hesitant to put him in. However the NY Times, IMDB, and the site for a movie he did were just three of the places to say it so it seems fairly solid. It's not unusual for OIs to strengthen in adulthood. Almost all of my fractures occurred before I was 14. (Although I still can't walk) If I briefly mention OI to the page on him would that be acceptable or too activist. I really am not any kind of activist of anything so wouldn't want to offend.--T. Anthony 06:28, 12 September 2005 (UTC)

Your edits are very welcome and have certainly added some good content to the article. I started it off a while back knowing very little about OI, so it's nice for someone that clearly knows what they are talking about to come along and expand it. As for Michael J. Anderson, I would agree with adding some information there as those three sources are reputable enough to show that it's true, and it is therefore an important part of his life. violet/riga (t) 06:46, 12 September 2005 (UTC)

Linked to the French one which seems to be the oldest of the four, and one of the best done perhaps. Although they spell it like "Osteogenie Imparfait"--T. Anthony 17:36, 12 November 2005 (UTC)

Contents 1 Needs referenced, huh? 2 Classification Expansion 3 Doing Research for Term Paper 4 Bisphosphonates 5 Dominate Hereditary Condition similar to OI 6 Scrubs 7 High Tolerance for Pain? 8 Not child abuse 9 Source/reference for death age? 10 Not everyone fits 11 Add reference to "Avian Bone Syndrome"?

[edit] Needs referenced, huh?

I took that off because I don't see what that's referring to. I have OI and most everything in this is mostly mainstream. The article has in least 8 citations and more now. There are some things about hormonal issues that strike me as a bit off, but the little citation { {fact} }(take out spaces) should've sufficed there.--T. Anthony 07:57, 10 January 2006 (UTC)

• The article has no reference section, and a few external links to show which famous people have the disorder. Listing a basic reference text and other sources that were used to write the article would be a good start.--nixie 08:03, 10 January 2006 (UTC)
  • Well okay, but there really aren't many texts on this. It's a condition that effects 1 in 15,000 people. Most of the books I find are long out of print. I certainly prefer books to links, but in this case that's not quite plausible. Still I tried on that.--T. Anthony 08:43, 10 January 2006 (UTC)
    • Thanks for adding all those refernces.--nixie 22:41, 10 January 2006 (UTC)
      • You're welcome. You do know though that I haven't read any of those books and it's mostly still based on the links, correct? I did take out links to non-scholarly places though.--T. Anthony 23:30, 10 January 2006 (UTC)

[edit] Classification Expansion

5/10/06: I'm a 4th year medical student working in a pathology lab, and I came across OI classifications that I had been unfamiliar with. I reviewed multiple pathology textbooks as well as the most recent literature (2 new references added.) Based on what I discovered, I expanded upon the classification system outlined in Wikipedia. Hope it is helpful and/or consistent with others' literature surveys. -Andrew

12/19/06: I noticed that someone changed the order of severity of the classifications from "Type I is the most common and mildest form, followed by Type IV, Type III and Type II." to "Type I is the most common and mildest form, followed by Type II, Type III and Type IV." While the latter/current statement is numerically chronologic, it suggests that Type IV is the most severe form. To the best of my review of the pathology texts, such is not the case, and the former sentence is more accurate. -Andrew

[edit] Doing Research for Term Paper

T. Anthony:

My uncle has OI and I have always been curious to learn more about the disease, that's why I chose it for my topic for my paper. I am wondering if you can help me with any more sources or any other information that might be useful for my paper. Everything I am finding is loaded down with so much medical terminology that I am having a hard time deciding what to write. Thanks.AngiH 02:57, 14 August 2006 (UTC)

Curiously I was not particularly interested in my condition until adulthood. It's just what I am, like being blue-eyed or a male. Anyway I'm assuming you checked the OIF correct? There's also OIF Europe which you might try. There are OIs with blogs and websites, in fact I think it might be fair to say there's a disproportionate amount of that. OI has no effect on intelligence, although there's disputed evidence that indicates we our average intelligence might be a bit better than average, but some of us are severe enough to be homebound for much of the time. Some I find are Wheelmansplace, Beyond Independence (A NASA engineer's site, All about Dave (he also has epilepsy, and many others. This article is also relatively good all things considered. Basically the main concerns for us are accidents and respiratory problems. I personally find advantages to it, but what advantages there are vary from person to person. Some OIs are "emotionally upbeat" compared to average people, I am and some studies indicate this is unusually common, but it is very far from universal. I've only rarely heard of OIs with clinical depression, but this might be my lack of knowledge, but I have heard of OIs who are depressed because of isolation or pain. This is all very anecdotal though, but you seemed to indicate you wanted less clinical.--T. Anthony 09:14, 25 August 2006 (UTC)

[edit] Bisphosphonates

Someone should edit the section that says Bisphosphonates do not affect adult OI patients. BP do increase bone mass in adults who are no longer growing; OI is no exception. BPs decrease bone resorption, leading to an overall increase in bone density. They are used for this purpose to treat osteoporosis in adults.

I'll get to it when I next get a chance, otherwise someone else can feel free to jump in. Dr Aaron 07:04, 1 September 2006 (UTC)

[edit] Dominate Hereditary Condition similar to OI

Hi, I came across this page through Recessive-Dominate genetics and genetically linked diseases, and this disease sounds very similar to something that affects my mother, sister, uncle, and affected my grandfather. It's known that the disease is hereditary, and dominant, it has caused weak bones among all of them, my mother in fact had a vertebra collapse simply from breast-feeding (after that she was told that she needed her calcium more than her newborn babies need natural breast milk.) My sister also has had numerous fractures throughout her life. A bone density test on my mother showed that she had density drastically and significantly under that necessary to diagnose Osteoperosis (surgeons repairing a fracture of her femur told us that it was like drilling into sugar cubes), and my sister at the age of 25 had a bone density scan that showed her to have the bones of a healthy 80-year old.

Although the primary issue is similar, (the weakness of bones, and their insufficient generation) There are quite a few symptoms. As those suffering from this disease in my family are relatively healthy otherwise, it is definitely not similar to Type II. As there is no known loss of hearing, nor a drop off of fractures after puberty, while accounting for the fact that they are simply more careful now. People don't go around pushing my sister off her tri-cycle anymore, and neither are people jumping on my mother's back.

But they are certainly just as susceptable to breaks, as evidenced by my sister falling simply from ice-skating and breaking her femur (again), and my mother falling in an airport from a people-mover at ground level to floor and breaking three limbs, sparing her right arm only because she was reaching out trying to catch herself.

There is also no bone disformity, the bones appear otherwise completely healthy.

In many ways this disease is similar to OI, and would certainly fit the meaning of the phrase "Osteogensis Imperfecta", but does not share many of the other effects that are related to OI. In many ways, it seems to impact similarly to and with symptoms that are much more like Osteoporosis, except not being age-related, and is definitely genetic. It's also known that it correlates with Hyperphosphatasemia after puberty but not before.

Would anyone with OI, or knowledgable of OI be able to say if it would be typical to have high levels of Alkaline Phosphatase after puberty but not before? The big related causes to hyperphosphatasemia, and related to bone disorders appear to be Paget's disease, and cancers of the bone (of which this is certainly not cancerous), and Paget's disease appears to not be genetic at all, and beside that, it is said to be rare in people under 40 years of age, I would think it unusual to have 4 people in a direct bloodline have paget's disease from the age of about 5.

Could anyone help me out with any information?

I've posted an answer on your talk page.

Dr Aaron 02:26, 3 October 2006 (UTC)

[edit] Scrubs

In the beginning of Season 5 of Scrubs (TV series), doesn't Elliot have an OI fellowship at a different hospital? And if so, shouldn't this be mentioned in the Potrayal in popular culture section? Mmace91 21:05, 14 October 2006 (UTC)

I haven't watched the show faithfully, but apparently she does have something like that.[1]--T. Anthony 13:50, 18 October 2006 (UTC)

[edit] High Tolerance for Pain?

My nephew has this and it has also been determined that he has a high tolerance for pain. I was wondering if this is common among OI patients. Because of his high tolerance, and lack of family history, his condition was not detected until he was nearly two years old, and not until after he was taken away from his family under accusations of child abuse. I believe a section on accusations of child abuse should be added as I understand it is pretty common. I'd add it myself but due to my family's experience I wouldn't be able to write it NPOV.nut-meg 04:02, 23 January 2007 (UTC)

I'm 16 and have OI and I too have a high tolerance of pain. My theory is that since we(people with OI) are born with this desease just naturally build a higher pain tolerance with each addional break. That being said, even though I have a higher level of tolerance I am still taking Pain killers such as fentanyl patches.

[edit] Not child abuse

We should add that there have been cases of kids being taken for there parents because Social Services thinks that the parents are abusing the kids when in fact the kids suffer from OI. I will start to work on it soon. Fswiergul 22:54, 28 March 2007 (UTC)

My family went through that. It was a nightmare, and I thnk it is an important aspect of this disease. Awareness is key. nut-meg 15:01, 29 March 2007 (UTC)

On the flipside there has been a few parents who claimed their kid had OI to get out of abuse charges, but then they found out the kid didn't. Also I know of at least one case where the kid had OI and she was the victim of abuse. (Her Mom flipped out and threw her down a staircase. (That story can not be put in the article as it's anecdotal, but cases of abusers falsely claiming OI are recorded)--T. Anthony 10:50, 24 April 2007 (UTC)

[edit] Source/reference for death age?

"Death before the age of 25 is common in Type IV, due to the increased pressure on the body from the curved spinal column. When a person with Type IV develops, all the organs are pushed into a body that is smaller and malformed, due to constant breaking. When the spine pressure is combined with organ pressure, the patient suffers a massive heart attack and dies."

-Is there a source/reference for this claim? I haven't seen it in any clinical research. Most research indicates that type IV life expectancy is normal or near normal. I'm going to remove this until a source is identified.

[edit] Not everyone fits

I was thinking we should add not everyone with OI fits perfectly into the types. I have had OVER 400 breaks and rebreaks, had to get my spine fused because of because of servere spine curvature, was born with multible freature in defferent stages of healing. But I don't have discolouration of the sclera,Loose joints, Poor muscle tone or hearing loss. I just think it would be nice to add.

Fswiergul 14:09, 19 September 2007 (UTC)

[edit] Add reference to "Avian Bone Syndrome"?

It would be good if someone added (in the popular culture references section) a mention of the "30 Rock" episodes in which a character had Avian Bone Syndrome. From Google results, it appears most people don't realize there is a real condition that that is based on (although portrayed in a wildly inaccurate way). 68.162.136.251 (talk) 12:37, 10 April 2008 (UTC)