MKL2

From Wikipedia, the free encyclopedia

MKL/myocardin-like 2

Identifiers

MKL2; DKFZp686J1745; FLJ31823; FLJ45623; MRTF-B; NPD001

External IDs

OMIM: 609463 MGI: 3050795 HomoloGene: 40917

Gene ontology
Molecular Function:	• nucleic acid binding • transcription coactivator activity • actin binding • identical protein binding
Cellular Component:	• nucleus • cytoplasm
Biological Process:	• transcription • regulation of transcription, DNA-dependent • multicellular organismal development • heart development • striated muscle development • cell differentiation • positive regulation of striated muscle development • positive regulation of transcription • positive regulation of transcription from RNA polymerase II promoter • blood vessel morphogenesis • smooth muscle cell differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014048 (mRNA)
NP_054767 (protein)

NM_153588 (mRNA)
NP_705816 (protein)

Location

Chr 16: 14.08 - 14.27 Mb

Chr 16: 13.27 - 13.33 Mb

Pubmed search

[1]

[2]

MKL/myocardin-like 2, also known as MKL2, is a human gene.^[1]

[edit] References

^ Entrez Gene: MKL2 MKL/myocardin-like 2.

[edit] Further reading

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99-106. PMID 12168954.
Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (5): 337-45. PMID 10574462.
Wang DZ, Li S, Hockemeyer D, et al. (2003). "Potentiation of serum response factor activity by a family of myocardin-related transcription factors.". Proc. Natl. Acad. Sci. U.S.A. 99 (23): 14855-60. doi:10.1073/pnas.222561499. PMID 12397177.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Cen B, Selvaraj A, Burgess RC, et al. (2003). "Megakaryoblastic leukemia 1, a potent transcriptional coactivator for serum response factor (SRF), is required for serum induction of SRF target genes.". Mol. Cell. Biol. 23 (18): 6597-608. PMID 12944485.
Selvaraj A, Prywes R (2004). "Megakaryoblastic leukemia-1/2, a transcriptional co-activator of serum response factor, is required for skeletal myogenic differentiation.". J. Biol. Chem. 278 (43): 41977-87. doi:10.1074/jbc.M305679200. PMID 14565952.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Morita T, Mayanagi T, Sobue K (2007). "Dual roles of myocardin-related transcription factors in epithelial mesenchymal transition via slug induction and actin remodeling.". J. Cell Biol. 179 (5): 1027-42. doi:10.1083/jcb.200708174. PMID 18056415.