From Wikipedia, the free encyclopedia
Marburg multiple sclerosis, also known as malignant, acute or fulminant multiple sclerosis, is considered one of the multiple sclerosis borderline diseases, which is a collection of diseases classified by some as MS variants and by others as different diseases. Other diseases in this group are Neuromyelitis optica (NMO), Balo concentric sclerosis and Schilder's disease.[1]
It took its name from Otto Marburg. It can be diagnosed in vivo with an MRI.[2]
It is usually lethal, but recently it has been found to be responsive to Mitoxantrone[3] and Alemtuzumab,[4] and it has also been responsive to autologous stem cells transplantation.[5]
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[edit] References
- ^ Fontaine B (2001). "Borderline forms of multiple sclerosis" (in French). Rev. Neurol. (Paris) 157 (8-9 Pt 2): 929–34. PMID 11787357.
- ^ In vivo MRI diagnosis
- ^ Responsiveness to Mitoxantrone
- ^ Alemtuzumab and craniotomy for severe acute demyelinating illness [1]
- ^ Kimiskidis VK, Sakellari I, Tsimourtou V, et al (2007). "Autologous stem-cell transplantation in malignant multiple sclerosis: a case with a favorable long-term outcome". doi:10.1177/1352458507082604. PMID 17942513.
