MAP1LC3B

From Wikipedia, the free encyclopedia

Microtubule-associated protein 1 light chain 3 beta

PDB rendering based on 1ugm.

Available structures: 1ugm, 1v49, 2z0d, 2z0e

Identifiers

Symbol(s)

MAP1LC3B; MAP1A/1BLC3

External IDs

MGI: 1914693 HomoloGene: 69359

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• intracellular • autophagic vacuole • microtubule • organelle membrane
Biological Process:	• ubiquitin cycle • autophagy

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_022818 (mRNA)
NP_073729 (protein)

NM_026160 (mRNA)
NP_080436 (protein)

Location

Chr 16: 85.98 - 86 Mb

n/a

Pubmed search

[1]

[2]

Microtubule-associated protein 1 light chain 3 beta, also known as MAP1LC3B, is a human gene.^[1]

The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for this gene in autophagy, a process that involves the bulk degradation of cytoplasmic component.^[1]

[edit] References

^ ^a ^b Entrez Gene: MAP1LC3B microtubule-associated protein 1 light chain 3 beta.

[edit] Further reading

Snásel J, Pichová I (1997). "The cleavage of host cell proteins by HIV-1 protease.". Folia Biol. (Praha) 42 (5): 227–30. PMID 8997639.
Tanida I, Ueno T, Kominami E (2005). "LC3 conjugation system in mammalian autophagy.". Int. J. Biochem. Cell Biol. 36 (12): 2503–18. doi:10.1016/j.biocel.2004.05.009. PMID 15325588.
Wallin M, Deinum J, Goobar L, Danielson UH (1990). "Proteolytic cleavage of microtubule-associated proteins by retroviral proteinases.". J. Gen. Virol. 71 ( Pt 9): 1985–91. PMID 2212989.
Kabeya Y, Mizushima N, Ueno T, et al. (2000). "LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.". EMBO J. 19 (21): 5720–8. doi:10.1093/emboj/19.21.5720. PMID 11060023.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
Tanida I, Tanida-Miyake E, Komatsu M, et al. (2002). "Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p.". J. Biol. Chem. 277 (16): 13739–44. doi:10.1074/jbc.M200385200. PMID 11825910.
Tanida I, Tanida-Miyake E, Nishitani T, et al. (2002). "Murine Apg12p has a substrate preference for murine Apg7p over three Apg8p homologs.". Biochem. Biophys. Res. Commun. 292 (1): 256–62. PMID 11890701.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
He H, Dang Y, Dai F, et al. (2003). "Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B.". J. Biol. Chem. 278 (31): 29278–87. doi:10.1074/jbc.M303800200. PMID 12740394.
Difilippantonio S, Chen Y, Pietas A, et al. (2003). "Gene expression profiles in human non-small and small-cell lung cancers.". Eur. J. Cancer 39 (13): 1936–47. PMID 12932674.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Yang YS, Song HD, Peng YD, et al. (2004). "The gene expression profiling of sporadic pheochromocytoma and novel full-length cDNAs cloning.". Endocr. Relat. Cancer 10 (4): 621–7. PMID 14713272.
Tanida I, Sou YS, Ezaki J, et al. (2004). "HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates.". J. Biol. Chem. 279 (35): 36268–76. doi:10.1074/jbc.M401461200. PMID 15187094.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMID 15231747.
Tanida I, Ueno T, Kominami E (2005). "Human light chain 3/MAP1LC3B is cleaved at its carboxyl-terminal Met121 to expose Gly120 for lipidation and targeting to autophagosomal membranes.". J. Biol. Chem. 279 (46): 47704–10. doi:10.1074/jbc.M407016200. PMID 15355958.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.