LTBP3

From Wikipedia, the free encyclopedia

Latent transforming growth factor beta binding protein 3

Identifiers

LTBP3; LTBP2; DKFZP586M2123; FLJ33431; FLJ39893; FLJ42533; FLJ44138; LTBP-3; pp6425

External IDs

OMIM: 602090 MGI: 1101355 HomoloGene: 7405

Gene ontology
Molecular Function:	• calcium ion binding • growth factor binding
Cellular Component:	• extracellular region
Biological Process:	• skeletal development • transforming growth factor beta receptor signaling pathway

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_021070 (mRNA)
NP_066548 (protein)

NM_008520 (mRNA)
NP_032546 (protein)

Location

Chr 11: 65.06 - 65.08 Mb

Chr 19: 5.74 - 5.76 Mb

Pubmed search

[1]

[2]

Latent transforming growth factor beta binding protein 3, also known as LTBP3, is a human gene.^[1]

[edit] References

^ Entrez Gene: LTBP3 latent transforming growth factor beta binding protein 3.

[edit] Further reading

Saharinen J, Hyytiäinen M, Taipale J, Keski-Oja J (2000). "Latent transforming growth factor-beta binding proteins (LTBPs)--structural extracellular matrix proteins for targeting TGF-beta action.". Cytokine Growth Factor Rev. 10 (2): 99-117. PMID 10743502.
Oklü R, Hesketh R (2001). "The latent transforming growth factor beta binding protein (LTBP) family.". Biochem. J. 352 Pt 3: 601-10. PMID 11104663.
Li X, Yin W, Pérez-Jurado L, et al. (1995). "Mapping of human and murine genes for latent TGF-beta binding protein-2 (LTBP2).". Mamm. Genome 6 (1): 42-5. PMID 7719025.
Morén A, Olofsson A, Stenman G, et al. (1995). "Identification and characterization of LTBP-2, a novel latent transforming growth factor-beta-binding protein.". J. Biol. Chem. 269 (51): 32469-78. PMID 7798248.
Michel K, Roth S, Trautwein C, et al. (1998). "Analysis of the expression pattern of the latent transforming growth factor beta binding protein isoforms in normal and diseased human liver reveals a new splice variant missing the proteinase-sensitive hinge region.". Hepatology 27 (6): 1592-9. doi:10.1002/hep.510270619. PMID 9620332.
Saharinen J, Keski-Oja J (2000). "Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta.". Mol. Biol. Cell 11 (8): 2691-704. PMID 10930463.
Brooke JS, Cha JH, Eidels L (2002). "Latent transforming growth factor beta-binding protein-3 and fibulin-1C interact with the extracellular domain of the heparin-binding EGF-like growth factor precursor.". BMC Cell Biol. 3: 2. PMID 11846885.
Chen Y, Dabovic B, Annes JP, Rifkin DB (2002). "Latent TGF-beta binding protein-3 (LTBP-3) requires binding to TGF-beta for secretion.". FEBS Lett. 517 (1-3): 277-80. PMID 12062452.
Penttinen C, Saharinen J, Weikkolainen K, et al. (2003). "Secretion of human latent TGF-beta-binding protein-3 (LTBP-3) is dependent on co-expression of TGF-beta.". J. Cell. Sci. 115 (Pt 17): 3457-68. PMID 12154076.
Ludbrook SB, Barry ST, Delves CJ, Horgan CM (2003). "The integrin alphavbeta3 is a receptor for the latency-associated peptides of transforming growth factors beta1 and beta3.". Biochem. J. 369 (Pt 2): 311-8. doi:10.1042/BJ20020809. PMID 12358597.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324-32. doi:10.1101/gr.2334104. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Koli K, Hyytiäinen M, Ryynänen MJ, Keski-Oja J (2005). "Sequential deposition of latent TGF-beta binding proteins (LTBPs) during formation of the extracellular matrix in human lung fibroblasts.". Exp. Cell Res. 310 (2): 370-82. doi:10.1016/j.yexcr.2005.08.008. PMID 16157329.
Kantola AK, Keski-Oja J, Koli K (2006). "Induction of human LTBP-3 promoter activity by TGF-beta1 is mediated by Smad3/4 and AP-1 binding elements.". Gene 363: 142-50. doi:10.1016/j.gene.2005.07.042. PMID 16223572.