LMO1

From Wikipedia, the free encyclopedia

LIM domain only 1 (rhombotin 1)

Identifiers

LMO1; MGC116692; RBTN1; RHOM1; TTG1

External IDs

OMIM: 186921 MGI: 102812 HomoloGene: 48101

Gene ontology
Molecular Function:	• transcription factor activity • zinc ion binding • metal ion binding
Cellular Component:	• nucleus
Biological Process:	• multicellular organismal development • cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002315 (mRNA)
NP_002306 (protein)

NM_057173 (mRNA)
NP_476514 (protein)

Location

Chr 11: 8.2 - 8.25 Mb

Chr 7: 108.93 - 108.93 Mb

Pubmed search

[1]

[2]

LIM domain only 1 (rhombotin 1), also known as LMO1, is a human gene.^[1]

LMO1 enocdes a cysteine-rich, two LIM domain transcriptional regulator. It is mapped to an area of consistent chromosomal translocation in chromosome 11, disrupting it in T-cell leukemia, although more rarely than the related gene, LMO2 is disrupted.^[1]

[edit] References

^ ^a ^b Entrez Gene: LMO1 LIM domain only 1 (rhombotin 1).

[edit] Further reading

Foroni L, Boehm T, White L, et al. (1992). "The rhombotin gene family encode related LIM-domain proteins whose differing expression suggests multiple roles in mouse development.". J. Mol. Biol. 226 (3): 747–61. PMID 1507224.
McGuire EA, Davis AR, Korsmeyer SJ (1991). "T-cell translocation gene 1 (Ttg-1) encodes a nuclear protein normally expressed in neural lineage cells.". Blood 77 (3): 599–606. PMID 1703797.
Boehm T, Foroni L, Kaneko Y, et al. (1991). "The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13.". Proc. Natl. Acad. Sci. U.S.A. 88 (10): 4367–71. PMID 2034676.
Boehm T, Spillantini MG, Sofroniew MV, et al. (1991). "Developmentally regulated and tissue specific expression of mRNAs encoding the two alternative forms of the LIM domain oncogene rhombotin: evidence for thymus expression.". Oncogene 6 (5): 695–703. PMID 2052354.
Chen Q, Cheng JT, Tasi LH, et al. (1990). "The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein.". EMBO J. 9 (2): 415–24. PMID 2303035.
Boehm T, Greenberg JM, Buluwela L, et al. (1990). "An unusual structure of a putative T cell oncogene which allows production of similar proteins from distinct mRNAs.". EMBO J. 9 (3): 857–68. PMID 2311586.
McGuire EA, Hockett RD, Pollock KM, et al. (1989). "The t(11;14)(p15;q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein.". Mol. Cell. Biol. 9 (5): 2124–32. PMID 2501659.
Boehm T, Baer R, Lavenir I, et al. (1988). "The mechanism of chromosomal translocation t(11;14) involving the T-cell receptor C delta locus on human chromosome 14q11 and a transcribed region of chromosome 11p15.". EMBO J. 7 (2): 385–94. PMID 3259177.
Wadman I, Li J, Bash RO, et al. (1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia.". EMBO J. 13 (20): 4831–9. PMID 7957052.
Valge-Archer VE, Osada H, Warren AJ, et al. (1994). "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells.". Proc. Natl. Acad. Sci. U.S.A. 91 (18): 8617–21. PMID 8078932.
Arber S, Caroni P (1996). "Specificity of single LIM motifs in targeting and LIM/LIM interactions in situ.". Genes Dev. 10 (3): 289–300. PMID 8595880.
Jurata LW, Kenny DA, Gill GN (1996). "Nuclear LIM interactor, a rhombotin and LIM homeodomain interacting protein, is expressed early in neuronal development.". Proc. Natl. Acad. Sci. U.S.A. 93 (21): 11693–8. PMID 8876198.
Ono Y, Fukuhara N, Yoshie O (1997). "Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL.". J. Biol. Chem. 272 (7): 4576–81. PMID 9020185.
Valge-Archer V, Forster A, Rabbitts TH (1999). "The LMO1 and LDB1 proteins interact in human T cell acute leukaemia with the chromosomal translocation t(11;14)(p15;q11).". Oncogene 17 (24): 3199–202. doi:10.1038/sj.onc.1202353. PMID 9872335.
Bao J, Talmage DA, Role LW, Gautier J (2000). "Regulation of neurogenesis by interactions between HEN1 and neuronal LMO proteins.". Development 127 (2): 425–35. PMID 10603358.
Cichutek A, Brueckmann T, Seipel B, et al. (2001). "Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1).". Cytogenet. Cell Genet. 93 (3-4): 277–83. PMID 11528126.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Lin YW, Deveney R, Barbara M, et al. (2005). "OLIG2 (BHLHB1), a bHLH transcription factor, contributes to leukemogenesis in concert with LMO1.". Cancer Res. 65 (16): 7151–8. doi:10.1158/0008-5472.CAN-05-1400. PMID 16103065.
Saeki N, Kim DH, Usui T, et al. (2007). "GASDERMIN, suppressed frequently in gastric cancer, is a target of LMO1 in TGF-beta-dependent apoptotic signalling.". Oncogene 26 (45): 6488–98. doi:10.1038/sj.onc.1210475. PMID 17471240.