KLF8

From Wikipedia, the free encyclopedia

Kruppel-like factor 8

Identifiers

KLF8; BKLF3; DKFZp686O08126; DXS741; MGC138314; ZNF741

External IDs

OMIM: 300286 MGI: 2442430 HomoloGene: 68549

Gene ontology
Molecular Function:	• DNA binding • zinc ion binding • metal ion binding
Cellular Component:	• intracellular • nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_007250 (mRNA)
NP_009181 (protein)

NM_173780 (mRNA)
NP_776141 (protein)

Location

Chr X: 56.28 - 56.33 Mb

Chr X: 148.7 - 148.74 Mb

Pubmed search

[1]

[2]

Kruppel-like factor 8, also known as KLF8, is a human gene.^[1]

[edit] References

^ Entrez Gene: KLF8 Kruppel-like factor 8.

[edit] Further reading

van Vliet J, Turner J, Crossley M (2000). "Human Krüppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription.". Nucleic Acids Res. 28 (9): 1955–62. PMID 10756197.
Lossi AM, Laugier-Anfossi F, Depetris D, et al. (2002). "Abnormal expression of the KLF8 (ZNF741) gene in a female patient with an X;autosome translocation t(X;21)(p11.2;q22.3) and non-syndromic mental retardation.". J. Med. Genet. 39 (2): 113–7. PMID 11836360.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Turner J, Nicholas H, Bishop D, et al. (2003). "The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2.". J. Biol. Chem. 278 (15): 12786–95. doi:10.1074/jbc.M300587200. PMID 12556451.
Zhao J, Bian ZC, Yee K, et al. (2003). "Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression.". Mol. Cell 11 (6): 1503–15. PMID 12820964.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMID 15772651.
Zhang P, Basu P, Redmond LC, et al. (2006). "A functional screen for Krüppel-like factors that regulate the human gamma-globin gene through the CACCC promoter element.". Blood Cells Mol. Dis. 35 (2): 227–35. doi:10.1016/j.bcmd.2005.04.009. PMID 16023392.
Wang X, Zhao J (2007). "KLF8 transcription factor participates in oncogenic transformation.". Oncogene 26 (3): 456–61. doi:10.1038/sj.onc.1209796. PMID 16832343.
Hu JH, Navas P, Cao H, et al. (2007). "Systematic RNAi studies on the role of Sp/KLF factors in globin gene expression and erythroid differentiation.". J. Mol. Biol. 366 (4): 1064–73. doi:10.1016/j.jmb.2006.12.047. PMID 17224162.
Wang X, Zheng M, Liu G, et al. (2007). "Krüppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion.". Cancer Res. 67 (15): 7184–93. doi:10.1158/0008-5472.CAN-06-4729. PMID 17671186.