Interleukin-3 receptor

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interleukin 3 receptor, alpha
Identifiers
Symbol	IL3RA
Alt. Symbols	CD123
HUGO	6012
OMIM	308385
Other data
Locus	Chr. X p22.3

interleukin 3 receptor, Y-Chromosomal
Identifiers
Symbol	IL3RA
Alt. Symbols	IL3RY, IL3RAY
Entrez	3563
HUGO	6012
OMIM	430000
Other data
Locus	Chr. Y p11.3

The interleukin-3 receptor (also known as CD123 antigen) is a molecule found on cells which helps transmit the signal of interleukin-3, a soluble cytokine important in the immune system.

The gene coding for the receptor is located in the pseudoautosomal region of the X and Y chromosomes.

The receptor belongs to the type I cytokine receptor family and is a heterodimer with a unique alpha chain paired with the common beta (beta c or CDw131) subunit.

The gene for the alpha subunit is 40 kilobases long and has 12 exons.

The receptor, found on pluripotent progenitor cells, induces tyrosine phosphorylation within the cell and promotes proliferation and differentiation within the hematopoietic cell lines.

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MeSH Interleukin-3+Receptor

v • d • e Transmembrane receptors: immune receptors

Cytokine receptor	Type I: Interleukins (2, 3, 4, 5, 6, 7, 9, 11, 12, 13, 15, 21, 23, 27), CSF receptors (EPO, GM-CSF, G-CSF), GH, prolactin, Oncostatin M,Leukemia inhibitory factor - common subunits (Common gamma chain, common beta chain, CSF2RB) Type II: Interleukins (10, 20, 22, 28) - interferon (-α/β, -γ) immunoglobulin superfamily: CSF1, C-kit, IL-1, IL-18 Tumor necrosis factor: CD27, CD30, CD40, CD120, Lymphotoxin β Chemokines: IL-8 (α, β), CCR1,CXCR4 Other: IL-17, TGF-beta (1, 2)

Pattern recognition/Toll-like	TLR 1 - TLR 2 - TLR 3 - TLR 4 - TLR 5 - TLR 6 - TLR 7 - TLR 8 - TLR 9 - TLR 10

Fc receptor	ε (FcεRI, FcεRII) - γ (FcγRI, FcγRII, FcγRIII) - α/μ (FcαRI, Fcα/μR) - Neonatal

Lymphocyte homing receptor	CD44 - L-selectin - VLA-4 - LFA-1

other	Antigen receptor (B-cell, T cell) - Complement - Formyl peptide - Immunophilins - Integrin - Killer-cell immunoglobulin-like - Scavenger