GUSB

From Wikipedia, the free encyclopedia

Glucuronidase, beta

PDB rendering based on 1bhg.

Available structures: 1bhg

Identifiers

Symbol(s)

GUSB; FLJ39445; MPS7

External IDs

OMIM: 253220 MGI: 95872 HomoloGene: 37271

Gene ontology
Molecular Function:	• beta-glucuronidase activity • cation binding
Cellular Component:	• lysosome
Biological Process:	• carbohydrate metabolic process • glycosaminoglycan catabolic process • metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000181 (mRNA)
NP_000172 (protein)

NM_010368 (mRNA)
NP_034498 (protein)

Location

Chr 7: 65.06 - 65.08 Mb

Chr 5: 130.27 - 130.29 Mb

Pubmed search

[1]

[2]

Glucuronidase, beta, also known as GUSB, is a human gene.^[1]

[edit] See also

Glucuronidase

[edit] References

^ Entrez Gene: GUSB glucuronidase, beta.

[edit] Further reading

Bell CE, Sly WS, Brot FE (1977). "Human beta-glucuronidase deficiency mucopolysaccharidosis: identification of cross-reactive antigen in cultured fibroblasts of deficient patients by enzyme immunoassay.". J. Clin. Invest. 59 (1): 97–105. PMID 401508.
Tanaka J, Gasa S, Sakurada K, et al. (1992). "Characterization of the subunits and sugar moiety of human placental and leukemic beta-glucuronidase.". Biol. Chem. Hoppe-Seyler 373 (1): 57–62. PMID 1311180.
Wolfe JH, Sands MS, Barker JE, et al. (1993). "Reversal of pathology in murine mucopolysaccharidosis type VII by somatic cell gene transfer.". Nature 360 (6406): 749–53. doi:10.1038/360749a0. PMID 1465145.
Tomatsu S, Fukuda S, Sukegawa K, et al. (1991). "Mucopolysaccharidosis type VII: characterization of mutations and molecular heterogeneity.". Am. J. Hum. Genet. 48 (1): 89–96. PMID 1702266.
Shipley JM, Miller RD, Wu BM, et al. (1991). "Analysis of the 5' flanking region of the human beta-glucuronidase gene.". Genomics 10 (4): 1009–18. PMID 1916806.
Ono M, Taniguchi N, Makita A, et al. (1988). "Phosphorylation of beta-glucuronidases from human normal liver and hepatoma by cAMP-dependent protein kinase.". J. Biol. Chem. 263 (12): 5884–9. PMID 2833520.
Oshima A, Kyle JW, Miller RD, et al. (1987). "Cloning, sequencing, and expression of cDNA for human beta-glucuronidase.". Proc. Natl. Acad. Sci. U.S.A. 84 (3): 685–9. PMID 3468507.
Guise KS, Korneluk RG, Waye J, et al. (1985). "Isolation and expression in Escherichia coli of a cDNA clone encoding human beta-glucuronidase.". Gene 34 (1): 105–10. PMID 3924735.
Ho YC, Ho LH, Ho KJ (1985). "Human hepatic beta-glucuronidase: an enzyme kinetic study.". Enzyme 33 (1): 9–17. PMID 3987656.
Shipley JM, Klinkenberg M, Wu BM, et al. (1993). "Mutational analysis of a patient with mucopolysaccharidosis type VII, and identification of pseudogenes.". Am. J. Hum. Genet. 52 (3): 517–26. PMID 7680524.
Vervoort R, Lissens W, Liebaers I (1994). "Molecular analysis of a patient with hydrops fetalis caused by beta-glucuronidase deficiency, and evidence for additional pseudogenes.". Hum. Mutat. 2 (6): 443–5. doi:10.1002/humu.1380020604. PMID 8111412.
Wu BM, Sly WS (1994). "Mutational studies in a patient with the hydrops fetalis form of mucopolysaccharidosis type VII.". Hum. Mutat. 2 (6): 446–57. doi:10.1002/humu.1380020605. PMID 8111413.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Moullier P, Bohl D, Heard JM, Danos O (1993). "Correction of lysosomal storage in the liver and spleen of MPS VII mice by implantation of genetically modified skin fibroblasts.". Nat. Genet. 4 (2): 154–9. doi:10.1038/ng0693-154. PMID 8348154.
Shipley JM, Grubb JH, Sly WS (1993). "The role of glycosylation and phosphorylation in the expression of active human beta-glucuronidase.". J. Biol. Chem. 268 (16): 12193–8. PMID 8505339.
Nishimura Y, Kato K, Himeno M (1996). "Biochemical characterization of liver microsomal, Golgi, lysosomal, and serum beta-glucuronidases in dibutyl phosphate-treated rats.". J. Biochem. 118 (1): 56–66. PMID 8537326.
Jain S, Drendel WB, Chen ZW, et al. (1996). "Structure of human beta-glucuronidase reveals candidate lysosomal targeting and active-site motifs.". Nat. Struct. Biol. 3 (4): 375–81. PMID 8599764.
Vervoort R, Islam MR, Sly WS, et al. (1996). "Molecular analysis of patients with beta-glucuronidase deficiency presenting as hydrops fetalis or as early mucopolysaccharidosis VII.". Am. J. Hum. Genet. 58 (3): 457–71. PMID 8644704.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Dentino AR, Raj PA, De Nardin E (1997). "Subtle differences between human and rabbit neutrophil receptors shown by the secretagogue activity of constrained formyl peptides.". Arch. Biochem. Biophys. 337 (2): 267–74. doi:10.1006/abbi.1996.9791. PMID 9016822.