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GSC (gene) - Wikipedia, the free encyclopedia

GSC (gene)

From Wikipedia, the free encyclopedia


Goosecoid
PDB rendering based on 2dmu.
Available structures: 2dmu
Identifiers
Symbol(s) GSC;
External IDs OMIM: 138890 MGI95841 HomoloGene7744
RNA expression pattern

More reference expression data

Orthologs
Human Mouse
Entrez 145258 14836
Ensembl ENSG00000133937 ENSMUSG00000021095
Uniprot P56915 Q02591
Refseq NM_173849 (mRNA)
NP_776248 (protein)
NM_010351 (mRNA)
NP_034481 (protein)
Location Chr 14: 94.3 - 94.31 Mb Chr 12: 104.87 - 104.87 Mb
Pubmed search [1] [2]

Goosecoid, also known as GSC, is a human gene.[1]

This gene encodes a member of the bicoid subfamily of the paired (PRD) homeobox family of proteins. The encoded protein acts as a transcription factor and may be autoregulatory. A similar protein in mice plays a role in craniofacial and rib cage development during embryogenesis.[1]

[edit] References

[edit] Further reading

  • Schlade-Bartusiak K, Macintyre G, Zunich J, Cox DW (2008). "A child with deletion (14)(q24.3q32.13) and auditory neuropathy.". Am. J. Med. Genet. A 146 (1): 117-23. doi:10.1002/ajmg.a.32064. PMID 18074379. 
  • Hartwell KA, Muir B, Reinhardt F, et al. (2007). "The Spemann organizer gene, Goosecoid, promotes tumor metastasis.". Proc. Natl. Acad. Sci. U.S.A. 103 (50): 18969-74. doi:10.1073/pnas.0608636103. PMID 17142318. 
  • Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621-5. doi:10.1126/science.1105776. PMID 15761153. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Namciu SJ, Friedman RD, Marsden MD, et al. (2004). "Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1.". Mamm. Genome 15 (3): 162-78. doi:10.1007/s00335-003-2311-y. PMID 15014966. 
  • Foucher I, Montesinos ML, Volovitch M, et al. (2003). "Joint regulation of the MAP1B promoter by HNF3beta/Foxa2 and Engrailed is the result of a highly conserved mechanism for direct interaction of homeoproteins and Fox transcription factors.". Development 130 (9): 1867-76. PMID 12642491. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Danilov V, Blum M, Schweickert A, et al. (1998). "Negative autoregulation of the organizer-specific homeobox gene goosecoid.". J. Biol. Chem. 273 (1): 627-35. PMID 9417125. 
  • Blum M, De Robertis EM, Kojis T, et al. (1994). "Molecular cloning of the human homeobox gene goosecoid (GSC) and mapping of the gene to human chromosome 14q32.1.". Genomics 21 (2): 388-93. doi:10.1006/geno.1994.1281. PMID 7916327. 


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