GPC4

From Wikipedia, the free encyclopedia

Glypican 4

Identifiers

GPC4; K-glypican

External IDs

OMIM: 300168 MGI: 104902 HomoloGene: 55582

Gene ontology
Molecular Function:	• GPI anchor binding
Cellular Component:	• proteinaceous extracellular matrix • integral to plasma membrane • membrane
Biological Process:	• cell proliferation • anatomical structure morphogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001448 (mRNA)
NP_001439 (protein)

XM_990413 (mRNA)
XP_995507 (protein)

Location

Chr X: 132.26 - 132.38 Mb

Chr X: 48.3 - 48.41 Mb

Pubmed search

[1]

[2]

Glypican 4, also known as GPC4, is a human gene.^[1]

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome.^[1]

[edit] References

^ ^a ^b Entrez Gene: GPC4 glypican 4.

[edit] Further reading

Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325-37. doi:10.1038/nature03440. PMID 15772651.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Sheu TJ, Schwarz EM, O'Keefe RJ, et al. (2002). "Use of a phage display technique to identify potential osteoblast binding sites within osteoclast lacunae.". J. Bone Miner. Res. 17 (5): 915-22. PMID 12009023.
Karumanchi SA, Jha V, Ramchandran R, et al. (2001). "Cell surface glypicans are low-affinity endostatin receptors.". Mol. Cell 7 (4): 811-22. PMID 11336704.
Hagihara K, Watanabe K, Chun J, Yamaguchi Y (2000). "Glypican-4 is an FGF2-binding heparan sulfate proteoglycan expressed in neural precursor cells.". Dev. Dyn. 219 (3): 353-67. doi:10.1002/1097-0177(2000)9999:9999<::AID-DVDY1059>3.0.CO;2-#. PMID 11066092.
Veugelers M, Cat BD, Muyldermans SY, et al. (2000). "Mutational analysis of the GPC3/GPC4 glypican gene cluster on Xq26 in patients with Simpson-Golabi-Behmel syndrome: identification of loss-of-function mutations in the GPC3 gene.". Hum. Mol. Genet. 9 (9): 1321-8. PMID 10814714.
Siebertz B, Stöcker G, Drzeniek Z, et al. (2000). "Expression of glypican-4 in haematopoietic-progenitor and bone-marrow-stromal cells.". Biochem. J. 344 Pt 3: 937-43. PMID 10585884.
Huber R, Mazzarella R, Chen CN, et al. (1999). "Glypican 3 and glypican 4 are juxtaposed in Xq26.1.". Gene 225 (1-2): 9-16. PMID 9931407.
Veugelers M, Vermeesch J, Watanabe K, et al. (1998). "GPC4, the gene for human K-glypican, flanks GPC3 on xq26: deletion of the GPC3-GPC4 gene cluster in one family with Simpson-Golabi-Behmel syndrome.". Genomics 53 (1): 1-11. doi:10.1006/geno.1998.5465. PMID 9787072.
Watanabe K, Yamada H, Yamaguchi Y (1995). "K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that is highly expressed in developing brain and kidney.". J. Cell Biol. 130 (5): 1207-18. PMID 7657705.