Glycerol kinase

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glycerol kinase
Identifiers
Symbol	GK
Entrez	2710
HUGO	4289
OMIM	300474
RefSeq	NM_000167
UniProt	P32189
Other data
EC number	2.7.1.30
Locus	Chr. X p21.3

Glycerol kinase is a phosphotransferase enzyme involved in lipolysis.

Glycerol kinase catalyzes the transfer of a phosphate from ATP to glycerol thus forming glycerol phosphate. Adipocytes lack glycerol kinase so they cannot metabolize the glycerol produced during triacyl glycerol degradation. This glycerol is instead shuttled to the liver via the blood where it is:

phosphorylated by glycerol kinase to glycerol phosphate
converted to DHAP (dihydroxyacetone phosphate) which can participate in glycolysis or gluconeogenesis.

[edit] See also

[edit] External links

MeSH Glycerol+Kinase

[edit] References

Biochemistry, Champe, P.C., Harvey, R.A., Ferrier, D.R., 3rd ed., 2005.

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v • d • e Transferases: Phosphotransferases/kinases (EC 2.7)

2.7.1 - OH acceptor	Hexo- - Gluco- - Fructo- (Hepatic fructo-) - Galacto- - Phosphofructo- (1, 2) - Riboflavin - Shikimate - Thymidine - NAD⁺ - Glycerol - Pantothenate - Mevalonate - Pyruvate - Deoxycytidine - PFP - Diacylglycerol - Bruton's tyrosine - Phosphoinositide 3 (Class I PI 3, Class II PI 3) - Sphingosine

2.7.2 - COOH acceptor	Phosphoglycerate - Aspartate

2.7.3 - N acceptor	Creatine

2.7.4 - PO₄ acceptor	Phosphomevalonate - Adenylate - Nucleoside-diphosphate

2.7.6 - P₂O₇	Ribose-phosphate diphosphokinase - Thiamine pyrophosphokinase

2.7.7 - nucleotidyl-	Integrase - PNPase - Polymerase - RNase PH - UDP-glucose pyrophosphorylase - Galactose-1-phosphate uridylyltransferase -Terminal deoxynucleotidyl transferase - RNA replicase - Reverse transcriptase (Telomerase) - Transposase

2.7.8 - other phos.	N-acetylglucosamine-1-phosphate transferase

2.7.10-11 - protein	Tyrosine - Serine/threonine-specific