Formins
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Formins (formin homology proteins) are a group of proteins that are involved in the polymerisation of actin and associate with the fast-growing end (barbed end) of actin filaments [1]. The structure of formins is mainly conserved in the C-terminal Formin Homology (FH) domains namely FH1, FH2 and the more loosely defined FH3 domain [2]. The actin nucleation-promoting activity of S. cerevisiae formins has been localized to the FH1-FH2 domains. Other commonly shared domains are a GTPase binding domain (GBD) that bind for example Cdc42 at the N-terminus, and a DAD or Dia-autoregulatory domain, toward the C-terminus.
[edit] References
- ^ Evangelista Marie, Zigmond Sally and Boone Charles (July 2003). "Formins: signaling effectors for assembly and polarization of actin filaments". J Cell Sci. 116 (Pt 13): 2603–11. doi:. PMID 12775772.
- ^ Wallar Bradley J and Alberts Arthur S (August 2003). "The formins: active scaffolds that remodel the cytoskeleton". Trends Cell Biol. 13 (8): 435–46. doi:. PMID 12888296.
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