FKBP3

From Wikipedia, the free encyclopedia

FK506 binding protein 3, 25kDa

PDB rendering based on 1pbk.

Available structures: 1pbk

Identifiers

Symbol(s)

FKBP3; PPIase; FKBP-25

External IDs

OMIM: 186947 MGI: 1353460 HomoloGene: 1525

Gene ontology
Molecular Function:	• peptidyl-prolyl cis-trans isomerase activity • receptor activity • FK506 binding • isomerase activity
Cellular Component:	• nucleus
Biological Process:	• protein folding

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002013 (mRNA)
NP_002004 (protein)

NM_013902 (mRNA)
NP_038930 (protein)

Location

Chr 14: 44.65 - 44.67 Mb

Chr 12: 65.98 - 65.99 Mb

Pubmed search

[1]

[2]

FK506 binding protein 3, 25kDa, also known as FKBP3, is a human gene.^[1]

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin.^[1]

[edit] References

^ ^a ^b Entrez Gene: FKBP3 FK506 binding protein 3, 25kDa.

[edit] Further reading

Hung DT, Schreiber SL (1992). "cDNA cloning of a human 25 kDa FK506 and rapamycin binding protein.". Biochem. Biophys. Res. Commun. 184 (2): 733–8. PMID 1374240.
Jin YJ, Burakoff SJ, Bierer BE (1992). "Molecular cloning of a 25-kDa high affinity rapamycin binding protein, FKBP25.". J. Biol. Chem. 267 (16): 10942–5. PMID 1375932.
Wiederrecht G, Martin MM, Sigal NH, Siekierka JJ (1992). "Isolation of a human cDNA encoding a 25 kDa FK-506 and rapamycin binding protein.". Biochem. Biophys. Res. Commun. 185 (1): 298–303. PMID 1376117.
Jin YJ, Burakoff SJ (1993). "The 25-kDa FK506-binding protein is localized in the nucleus and associates with casein kinase II and nucleolin.". Proc. Natl. Acad. Sci. U.S.A. 90 (16): 7769–73. PMID 7689229.
Cross SH, Charlton JA, Nan X, Bird AP (1994). "Purification of CpG islands using a methylated DNA binding column.". Nat. Genet. 6 (3): 236–44. doi:10.1038/ng0394-236. PMID 8012384.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Yang WM, Yao YL, Seto E (2001). "The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1.". EMBO J. 20 (17): 4814–25. doi:10.1093/emboj/20.17.4814. PMID 11532945.
Meng X, Chen J, Yang Q, et al. (2003). "Cloning and identification of a novel cDNA which may be associated with FKBP25.". Biochem. Genet. 40 (9-10): 303–10. PMID 12392168.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Won J, Kim M, Yi YW, et al. (2005). "A magnetic nanoprobe technology for detecting molecular interactions in live cells.". Science 309 (5731): 121–5. doi:10.1126/science.1112869. PMID 15994554.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.