Etafedrine
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Etafedrine
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| Systematic (IUPAC) name | |
| 2-(ethyl-methylamino)-1-phenylpropan-1-ol | |
| Identifiers | |
| CAS number | 7681-79-0 (hydrochloride) |
| ATC code | ? |
| PubChem | |
| Chemical data | |
| Formula | C12H19NO |
| Mol. mass | 193.285 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
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| Legal status | |
| Routes | ? |
Etafedrine (INN) or ethylephedrine is a long-acting bronchodilator and has the brand name Nethaprin. It is commercially available as both the free base, and as the hydrochloride.
It is no longer marketed by Sanofi-Aventis.
[edit] Synthesis
Ethylephedrine may be synthesized by alkylating ephedrine with ethyl iodide. The hydrochloride may be prepared by passing hydrogen chloride through a solution of ethylephedrine in diethyl ether.[1]
[edit] References
- ^ Takeo Ueda,Shigeshi Toyoshima,Kiyoshi Takahashi and Masako Muraoka (1955). "Studies on Syntheses and Pharmacological Effects of N-Alkylephedrines and their Ammonium Salt Derivatives" (Free full text). Pharm. Bull. (Japan) 3 (6): 465–468.
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