ERAF

From Wikipedia, the free encyclopedia

Erythroid associated factor

PDB rendering based on 1w09.

Available structures: 1w09, 1w0a, 1w0b, 1xzy, 1y01, 1z8u

Identifiers

Symbol(s)

ERAF; AHSP; EDRF

External IDs

OMIM: 605821 HomoloGene: 9605

Gene ontology
Molecular Function:	• hemoglobin binding • unfolded protein binding
Cellular Component:	• hemoglobin complex
Biological Process:	• protein folding • hemoglobin metabolic process • hemopoiesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

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n/a

Refseq

NM_016633 (mRNA)
NP_057717 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 16: 31.45 - 31.45 Mb

n/a

Pubmed search

[1]

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Erythroid associated factor, also known as ERAF, is a human gene.^[1]

[edit] References

^ Entrez Gene: ERAF erythroid associated factor.

[edit] Further reading

Florio P, Rossi M, Sigurdardottir M, et al. (2004). "Paracrine regulation of endometrial function: interaction between progesterone and corticotropin-releasing factor (CRF) and activin A.". Steroids 68 (10-13): 801–7. PMID 14667971.
Weiss MJ, Zhou S, Feng L, et al. (2006). "Role of alpha-hemoglobin-stabilizing protein in normal erythropoiesis and beta-thalassemia.". Ann. N. Y. Acad. Sci. 1054: 103–17. doi:10.1196/annals.1345.013. PMID 16339656.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. PMID 11042152.
Miele G, Manson J, Clinton M (2001). "A novel erythroid-specific marker of transmissible spongiform encephalopathies.". Nat. Med. 7 (3): 361–4. doi:10.1038/85515. PMID 11231637.
Kihm AJ, Kong Y, Hong W, et al. (2002). "An abundant erythroid protein that stabilizes free alpha-haemoglobin.". Nature 417 (6890): 758–63. doi:10.1038/nature00803. PMID 12066189.
Gell D, Kong Y, Eaton SA, et al. (2002). "Biophysical characterization of the alpha-globin binding protein alpha-hemoglobin stabilizing protein.". J. Biol. Chem. 277 (43): 40602–9. doi:10.1074/jbc.M206084200. PMID 12192002.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Viprakasit V, Tanphaichitr VS, Chinchang W, et al. (2004). "Evaluation of alpha hemoglobin stabilizing protein (AHSP) as a genetic modifier in patients with beta thalassemia.". Blood 103 (9): 3296–9. doi:10.1182/blood-2003-11-3957. PMID 14715623.
Baudin-Creuza V, Vasseur-Godbillon C, Pato C, et al. (2004). "Transfer of human alpha- to beta-hemoglobin via its chaperone protein: evidence for a new state.". J. Biol. Chem. 279 (35): 36530–3. doi:10.1074/jbc.M405389200. PMID 15220346.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Gallagher PG, Liem RI, Wong E, et al. (2006). "GATA-1 and Oct-1 are required for expression of the human alpha-hemoglobin-stabilizing protein gene.". J. Biol. Chem. 280 (47): 39016–23. doi:10.1074/jbc.M506062200. PMID 16186125.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Hamdane D, Vasseur-Godbillon C, Baudin-Creuza V, et al. (2007). "Reversible hexacoordination of alpha-hemoglobin-stabilizing protein (AHSP)/alpha-hemoglobin Versus pressure. Evidence for protection of the alpha-chains by their chaperone.". J. Biol. Chem. 282 (9): 6398–404. doi:10.1074/jbc.M610543200. PMID 17194704.