DNA replication factor CDT1

From Wikipedia, the free encyclopedia

Chromatin licensing and DNA replication factor 1

Identifiers

CDT1; DUP; RIS2

External IDs

OMIM: 605525 MGI: 1914427 HomoloGene: 32650

Gene ontology
Molecular Function:	• DNA binding • protein binding
Cellular Component:	• nucleus • replication fork
Biological Process:	• DNA replication checkpoint • DNA replication • cell cycle • regulation of S phase of mitotic cell cycle • regulation of DNA replication initiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_030928 (mRNA)
NP_112190 (protein)

NM_026014 (mRNA)
NP_080290 (protein)

Location

Chr 16: 87.4 - 87.4 Mb

Chr 8: 125.45 - 125.46 Mb

Pubmed search

[1]

[2]

Chromatin licensing and DNA replication factor 1, also known as CDT1, is a human gene.^[1] Its gene product is a protein part of a licensing complex with the protein Cdc6, and its activity during the cell cycle is tightly regulated by its association with the protein geminin, which both activates and inhibits Cdt1 at points in the cell cycle.

[edit] References

^ Entrez Gene: CDT1 chromatin licensing and DNA replication factor 1.

[edit] Further reading

Xouri G, Dimaki M, Bastiaens PI, Lygerou Z (2007). "Cdt1 interactions in the licensing process: a model for dynamic spatiotemporal control of licensing.". Cell Cycle 6 (13): 1549–52. PMID 17598984.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.
Nishitani H, Lygerou Z, Nishimoto T, Nurse P (2000). "The Cdt1 protein is required to license DNA for replication in fission yeast.". Nature 404 (6778): 625–8. doi:10.1038/35007110. PMID 10766248.
Whittaker AJ, Royzman I, Orr-Weaver TL (2000). "Drosophila double parked: a conserved, essential replication protein that colocalizes with the origin recognition complex and links DNA replication with mitosis and the down-regulation of S phase transcripts.". Genes Dev. 14 (14): 1765–76. PMID 10898791.
Wohlschlegel JA, Dwyer BT, Dhar SK, et al. (2001). "Inhibition of eukaryotic DNA replication by geminin binding to Cdt1.". Science 290 (5500): 2309–12. doi:10.1126/science.290.5500.2309. PMID 11125146.
Nishitani H, Taraviras S, Lygerou Z, Nishimoto T (2002). "The human licensing factor for DNA replication Cdt1 accumulates in G1 and is destabilized after initiation of S-phase.". J. Biol. Chem. 276 (48): 44905–11. doi:10.1074/jbc.M105406200. PMID 11555648.
Rialland M, Sola F, Santocanale C (2002). "Essential role of human CDT1 in DNA replication and chromatin licensing.". J. Cell. Sci. 115 (Pt 7): 1435–40. PMID 11896191.
Yanagi K, Mizuno T, You Z, Hanaoka F (2002). "Mouse geminin inhibits not only Cdt1-MCM6 interactions but also a novel intrinsic Cdt1 DNA binding activity.". J. Biol. Chem. 277 (43): 40871–80. doi:10.1074/jbc.M206202200. PMID 12192004.
Bermejo R, Vilaboa N, Calés C (2003). "Regulation of CDC6, geminin, and CDT1 in human cells that undergo polyploidization.". Mol. Biol. Cell 13 (11): 3989–4000. doi:10.1091/mbc.E02-04-0217. PMID 12429841.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Li X, Zhao Q, Liao R, et al. (2003). "The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation.". J. Biol. Chem. 278 (33): 30854–8. doi:10.1074/jbc.C300251200. PMID 12840033.
Cook JG, Chasse DA, Nevins JR (2004). "The regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cells.". J. Biol. Chem. 279 (10): 9625–33. doi:10.1074/jbc.M311933200. PMID 14672932.
Sugimoto N, Tatsumi Y, Tsurumi T, et al. (2004). "Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding.". J. Biol. Chem. 279 (19): 19691–7. doi:10.1074/jbc.M313175200. PMID 14993212.
Liu E, Li X, Yan F, et al. (2004). "Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation.". J. Biol. Chem. 279 (17): 17283–8. doi:10.1074/jbc.C300549200. PMID 15004027.
Ramachandran N, Hainsworth E, Bhullar B, et al. (2004). "Self-assembling protein microarrays.". Science 305 (5680): 86–90. doi:10.1126/science.1097639. PMID 15232106.
Ballabeni A, Melixetian M, Zamponi R, et al. (2005). "Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis.". EMBO J. 23 (15): 3122–32. doi:10.1038/sj.emboj.7600314. PMID 15257290.
Saxena S, Yuan P, Dhar SK, et al. (2004). "A dimerized coiled-coil domain and an adjoining part of geminin interact with two sites on Cdt1 for replication inhibition.". Mol. Cell 15 (2): 245–58. doi:10.1016/j.molcel.2004.06.045. PMID 15260975.
Kulartz M, Knippers R (2004). "The replicative regulator protein geminin on chromatin in the HeLa cell cycle.". J. Biol. Chem. 279 (40): 41686–94. doi:10.1074/jbc.M405798200. PMID 15284237.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.