CNP (gene)

From Wikipedia, the free encyclopedia

2',3'-cyclic nucleotide 3' phosphodiesterase

PDB rendering based on 1woj.

Available structures: 1woj

Identifiers

Symbol(s)

CNP; CNP1

External IDs

OMIM: 123830 MGI: 88437 HomoloGene: 7672

Gene ontology
Molecular Function:	• 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity • hydrolase activity
Cellular Component:	• membrane fraction • membrane
Biological Process:	• synaptic transmission • axonogenesis • adult locomotory behavior • cyclic nucleotide catabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_033133 (mRNA)
NP_149124 (protein)

NM_009923 (mRNA)
NP_034053 (protein)

Location

Chr 17: 37.37 - 37.38 Mb

Chr 11: 100.39 - 100.4 Mb

Pubmed search

[1]

[2]

2',3'-cyclic nucleotide 3' phosphodiesterase, also known as CNP, is a human gene.^[1]

[edit] References

^ Entrez Gene: CNP 2',3'-cyclic nucleotide 3' phosphodiesterase.

[edit] Further reading

Thompson RJ (1992). "2',3'-cyclic nucleotide-3'-phosphohydrolase and signal transduction in central nervous system myelin.". Biochem. Soc. Trans. 20 (3): 621–6. PMID 1385234.
Leroy MJ, Dumler I, Lugnier C, et al. (1992). "A new peptide (1150Da) selectively activates the calcium-calmodulin sensitive isoform of cyclic nucleotide phosphodiesterase from human myometrium.". Biochem. Biophys. Res. Commun. 184 (2): 700–5. PMID 1315529.
Sprinkle TJ, Lanclos KD, Lapp DF (1992). "Assignment of the human 2',3'-cyclic nucleotide 3'-phosphohydrolase gene to chromosome 17.". Genomics 13 (3): 877–80. PMID 1322358.
Douglas AJ, Fox MF, Abbott CM, et al. (1992). "Structure and chromosomal localization of the human 2',3'-cyclic nucleotide 3'-phosphodiesterase gene.". Ann. Hum. Genet. 56 (Pt 3): 243–54. PMID 1360194.
Staugaitis SM, Bernier L, Smith PR, Colman DR (1990). "Expression of the oligodendrocyte marker 2'3'-cyclic nucleotide 3'-phosphodiesterase in non-glial cells.". J. Neurosci. Res. 25 (4): 556–60. doi:10.1002/jnr.490250413. PMID 2161933.
Agrawal HC, Sprinkle TJ, Agrawal D (1990). "2',3'-cyclic nucleotide-3'-phosphodiesterase in the central nervous system is fatty-acylated by thioester linkage.". J. Biol. Chem. 265 (20): 11849–53. PMID 2164018.
Kurihara T, Takahashi Y, Nishiyama A, Kumanishi T (1988). "cDNA cloning and amino acid sequence of human brain 2',3'-cyclic-nucleotide 3'-phosphodiesterase.". Biochem. Biophys. Res. Commun. 152 (2): 837–42. PMID 2835044.
Sprinkle TJ, McMorris FA, Yoshino J, DeVries GH (1985). "Differential expression of 2':3'-cyclic nucleotide 3'-phosphodiesterase in cultured central, peripheral, and extraneural cells.". Neurochem. Res. 10 (7): 919–31. PMID 2995854.
Sheedlo HJ, Doran JE, Sprinkle TJ (1984). "An investigation of 2':3'-cyclic nucleotide 3'-phosphodiesterase (EC 3.1.4.37, CNP) in peripheral blood elements and CNS myelin.". Life Sci. 34 (18): 1731–7. PMID 6328143.
Monoh K, Kurihara T, Takahashi Y, et al. (1993). "Structure, expression and chromosomal localization of the gene encoding human 2',3'-cyclic-nucleotide 3'-phosphodiesterase.". Gene 129 (2): 297–301. PMID 8392017.
Löbbert RW, Winterpacht A, Seipel B, Zabel BU (1997). "Molecular cloning and chromosomal assignment of the human homologue of the rat cGMP-inhibited phosphodiesterase 1 (PDE3A)--a gene involved in fat metabolism located at 11p 15.1.". Genomics 37 (2): 211–8. doi:10.1006/geno.1996.0544. PMID 8921398.
Stricker R, Kalbacher H, Reiser G (1997). "The epitope recognized by a monoclonal antibody in the myelin-associated protein CNP.". Biochem. Biophys. Res. Commun. 237 (2): 266–70. PMID 9268698.
O'Neill RC, Braun PE (2000). "Selective synthesis of 2',3'-cyclic nucleotide 3'-phosphodiesterase isoform 2 and identification of specifically phosphorylated serine residues.". J. Neurochem. 74 (2): 540–6. PMID 10646504.
Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.". FASEB J. 15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID 11156964.
Bifulco M, Laezza C, Stingo S, Wolff J (2002). "2',3'-Cyclic nucleotide 3'-phosphodiesterase: a membrane-bound, microtubule-associated protein and membrane anchor for tubulin.". Proc. Natl. Acad. Sci. U.S.A. 99 (4): 1807–12. doi:10.1073/pnas.042678799. PMID 11842207.
Davidoff MS, Middendorff R, Köfüncü E, et al. (2002). "Leydig cells of the human testis possess astrocyte and oligodendrocyte marker molecules.". Acta Histochem. 104 (1): 39–49. PMID 11993850.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Basrur V, Yang F, Kushimoto T, et al. (2003). "Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.". J. Proteome Res. 2 (1): 69–79. PMID 12643545.
Kozlov G, Lee J, Elias D, et al. (2003). "Structural evidence that brain cyclic nucleotide phosphodiesterase is a member of the 2H phosphodiesterase superfamily.". J. Biol. Chem. 278 (46): 46021–8. doi:10.1074/jbc.M305176200. PMID 12947117.