Talk:Chronic myelogenous leukemia
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where did chronic myeloid leukemia originate? from india?
- In Japan. No, seriously, do you mean the origin of the malignant cells, or the origin of the term?
- The cells come from the bone marrow. The term was probably coined in the 19th century in Germany. JFW | T@lk 21:05, 7 Apr 2005 (UTC)
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[edit] can it harm the baby if you are pregnant?
Why are you asking? If this concerns yourself you should be asking your doctor. JFW | T@lk 07:47, 15 November 2005 (UTC)
[edit] HSCT since imatinib
doi:10.1111/j.1365-2141.2007.06582.x - imatinib has markedly reduced need for bone marrow transplant in CML. JFW | T@lk 22:56, 2 May 2007 (UTC)
[edit] CGL
should say somewhere that also called CGL. chronic granulocytic leukemia.
[edit] Review
Lancet review today doi:10.1016/S0140-6736(07)61165-9 JFW | T@lk 15:05, 27 July 2007 (UTC)
- Also an excellent review in the "How I treat..." section of Blood recently: PMID 17626839. And a very important study on drug treatment (e.g. imatinib and sons) vs. transplantation also came out in the past month in Blood: PMID 17317858. We should work these in. This article has been on my improvement list for a long time, but I haven't got around to it yet. Maybe we should start? It's about 50% of the way to being a very solid article. MastCell Talk 17:13, 27 July 2007 (UTC)
You fire the first salvo. After your golden touch to the AML article I trust this one is in good hands. JFW | T@lk 10:37, 31 July 2007 (UTC)
- The J Clin Invest has a theme issue about Ph. May be useful. Here JFW | T@lk 20:38, 2 August 2007 (UTC)
[edit] References for drug trials
This is my humble opinion, but we shouldn't use commercial pharmaceutical company websites as references for any drug trials. First of all, FDA labeling prevents them from saying anything. Secondly, they're really meant for investors rather than anyone trying to understand this disease. I'll look up some primary research and fix the references on those trials. BTW, the commercial websites could be put in the additional reading section. OrangeMarlin Talk• Contributions 00:06, 8 September 2007 (UTC)
[edit] PP2A
bcr-abl is only the first step in a cascade of oncogenesis. It seems PP2A plays a role, and PP2A inhibitors are doing interesting things doi:10.1172/JCI31095 JFW | T@lk 14:46, 10 September 2007 (UTC)
[edit] Convention
- Genes are written in small letters like "abl" and not "ABL"
- The gene transcripts or proteins are written in cabitals; eg: "abl" gene transcript is called "ABL"
- I made the necessary correction long back but someone reverted it.
- Thus, this article contains gross conventional mistakes.
- Please discuss and correct.
