CHEK1

From Wikipedia, the free encyclopedia

CHK1 checkpoint homolog (S. pombe)

PDB rendering based on 1ia8.

Available structures: 1ia8, 1nvq, 1nvr, 1nvs, 1zlt, 1zys, 2ayp, 2br1, 2brb, 2brg, 2brh, 2brm, 2brn, 2bro, 2c3j, 2c3k, 2c3l, 2cgu, 2cgv, 2cgw, 2cgx, 2gdo, 2ghg, 2hog, 2ywp

Identifiers

Symbol(s)

CHEK1; CHK1

External IDs

OMIM: 603078 MGI: 1202065 HomoloGene: 975

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • protein binding • ATP binding • transferase activity
Cellular Component:	• condensed nuclear chromosome • nucleus • replication fork
Biological Process:	• DNA damage checkpoint • regulation of cyclin-dependent protein kinase activity • G2/M transition of mitotic cell cycle • DNA repair • protein amino acid phosphorylation • cell cycle • meiotic recombination • gamete generation • negative regulation of cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001274 (mRNA)
NP_001265 (protein)

NM_007691 (mRNA)
NP_031717 (protein)

Location

Chr 11: 125 - 125.03 Mb

Chr 9: 36.46 - 36.48 Mb

Pubmed search

[1]

[2]

CHK1 checkpoint homolog (S. pombe), also known as CHEK1, is a human gene.

[edit] Further reading

Giaccia AJ, Kastan MB (1998). "The complexity of p53 modulation: emerging patterns from divergent signals.". Genes Dev. 12 (19): 2973–83. PMID 9765199.
Kastan MB, Lim DS (2001). "The many substrates and functions of ATM.". Nat. Rev. Mol. Cell Biol. 1 (3): 179–86. doi:10.1038/35043058. PMID 11252893.
Chini CC, Chen J (2005). "Claspin, a regulator of Chk1 in DNA replication stress pathway.". DNA Repair (Amst.) 3 (8-9): 1033–7. doi:10.1016/j.dnarep.2004.03.001. PMID 15279790.
Sanchez Y, Wong C, Thoma RS, et al. (1997). "Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25.". Science 277 (5331): 1497–501. PMID 9278511.
Peng CY, Graves PR, Thoma RS, et al. (1997). "Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216.". Science 277 (5331): 1501–5. PMID 9278512.
Flaggs G, Plug AW, Dunks KM, et al. (1998). "Atm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes.". Curr. Biol. 7 (12): 977–86. PMID 9382850.
Ouyang B, Li W, Pan H, et al. (1999). "The physical association and phosphorylation of Cdc25C protein phosphatase by Prk.". Oncogene 18 (44): 6029–36. doi:10.1038/sj.onc.1202983. PMID 10557092.
Kim ST, Lim DS, Canman CE, Kastan MB (2000). "Substrate specificities and identification of putative substrates of ATM kinase family members.". J. Biol. Chem. 274 (53): 37538–43. PMID 10608806.
Shieh SY, Ahn J, Tamai K, et al. (2000). "The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites.". Genes Dev. 14 (3): 289–300. PMID 10673501.
Graves PR, Yu L, Schwarz JK, et al. (2000). "The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01.". J. Biol. Chem. 275 (8): 5600–5. PMID 10681541.
Semba S, Ouyang H, Han SY, et al. (2000). "Analysis of the candidate target genes for mutation in microsatellite instability-positive cancers of the colorectum, stomach, and endometrium.". Int. J. Oncol. 16 (4): 731–7. PMID 10717241.
Chen P, Luo C, Deng Y, et al. (2000). "The 1.7 A crystal structure of human cell cycle checkpoint kinase Chk1: implications for Chk1 regulation.". Cell 100 (6): 681–92. PMID 10761933.
Liu Q, Guntuku S, Cui XS, et al. (2000). "Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint.". Genes Dev. 14 (12): 1448–59. PMID 10859164.
Bulavin DV, Higashimoto Y, Popoff IJ, et al. (2001). "Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase.". Nature 411 (6833): 102–7. doi:10.1038/35075107. PMID 11333986.
Zhao H, Piwnica-Worms H (2001). "ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1.". Mol. Cell. Biol. 21 (13): 4129–39. doi:10.1128/MCB.21.13.4129-4139.2001. PMID 11390642.
Feijoo C, Hall-Jackson C, Wu R, et al. (2001). "Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing.". J. Cell Biol. 154 (5): 913–23. doi:10.1083/jcb.200104099. PMID 11535615.
Xie S, Wu H, Wang Q, et al. (2001). "Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway.". J. Biol. Chem. 276 (46): 43305–12. doi:10.1074/jbc.M106050200. PMID 11551930.
Latonen L, Taya Y, Laiho M (2001). "UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts.". Oncogene 20 (46): 6784–93. doi:10.1038/sj.onc.1204883. PMID 11709713.