Caldesmon

From Wikipedia, the free encyclopedia

Caldesmon 1

Identifiers

CALD1; CDM; H-CAD; L-CAD; MGC21352; NAG22

External IDs

Gene ontology
Molecular Function:	• actin binding • calmodulin binding • tropomyosin binding • myosin binding
Cellular Component:	• membrane fraction • cytoskeleton • actin cap
Biological Process:	• cell motility • muscle contraction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

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Refseq

NM_004342 (mRNA)
NP_004333 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 7: 134.11 - 134.31 Mb

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Pubmed search

[1]

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Caldesmon 1, also known as CALD1, is a human gene.^[1]

Caldesmon is a calmodulin binding protein. Like calponin, caldesmon tonically inhibits the ATPase activity of myosin in smooth muscle.

This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca⁺⁺-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca⁺⁺-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.^[1]

[edit] References

^ ^a ^b Entrez Gene: CALD1 caldesmon 1.

[edit] Further reading

Huber PA (1998). "Caldesmon.". Int. J. Biochem. Cell Biol. 29 (8-9): 1047–51. PMID 9415999.
Gusev NB (2002). "Some properties of caldesmon and calponin and the participation of these proteins in regulation of smooth muscle contraction and cytoskeleton formation.". Biochemistry Mosc. 66 (10): 1112–21. PMID 11736632.
Wang CL (2002). "Caldesmon and smooth-muscle regulation.". Cell Biochem. Biophys. 35 (3): 275–88. PMID 11894847.
Mani RS, McCubbin WD, Kay CM (1992). "Calcium-dependent regulation of caldesmon by an 11-kDa smooth muscle calcium-binding protein, caltropin.". Biochemistry 31 (47): 11896–901. PMID 1445920.
Hayashi K, Yano H, Hashida T, et al. (1993). "Genomic structure of the human caldesmon gene.". Proc. Natl. Acad. Sci. U.S.A. 89 (24): 12122–6. PMID 1465449.
Humphrey MB, Herrera-Sosa H, Gonzalez G, et al. (1992). "Cloning of cDNAs encoding human caldesmons.". Gene 112 (2): 197–204. PMID 1555769.
Adam LP, Gapinski CJ, Hathaway DR (1992). "Phosphorylation sequences in h-caldesmon from phorbol ester-stimulated canine aortas.". FEBS Lett. 302 (3): 223–6. PMID 1601129.
Novy RE, Lin JL, Lin JJ (1991). "Characterization of cDNA clones encoding a human fibroblast caldesmon isoform and analysis of caldesmon expression in normal and transformed cells.". J. Biol. Chem. 266 (25): 16917–24. PMID 1885618.
Horiuchi KY, Chacko S (1989). "Interaction between caldesmon and tropomyosin in the presence and absence of smooth muscle actin.". Biochemistry 27 (22): 8388–93. PMID 3242591.
der Terrossian E, Deprette C, Lebbar I, Cassoly R (1994). "Purification and characterization of erythrocyte caldesmon. Hypothesis for an actin-linked regulation of a contractile activity in the red blood cell membrane.". Eur. J. Biochem. 219 (1-2): 503–11. PMID 8307018.
Surgucheva I, Bryan J (1996). "Over-expression of smooth muscle caldesmon in mouse fibroblasts.". Cell Motil. Cytoskeleton 32 (3): 233–43. doi:10.1002/cm.970320307. PMID 8581978.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Graether SP, Heinonen TY, Raharjo WH, et al. (1997). "Tryptophan residues in caldesmon are major determinants for calmodulin binding.". Biochemistry 36 (2): 364–9. doi:10.1021/bi962008k. PMID 9003189.
Wang Z, Danielsen AJ, Maihle NJ, McManus MJ (1999). "Tyrosine phosphorylation of caldesmon is required for binding to the Shc.Grb2 complex.". J. Biol. Chem. 274 (47): 33807–13. PMID 10559276.
Adam L, Vadlamudi R, Mandal M, et al. (2000). "Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1.". J. Biol. Chem. 275 (16): 12041–50. PMID 10766836.
Hall SM, Hislop AA, Pierce CM, Haworth SG (2000). "Prenatal origins of human intrapulmonary arteries: formation and smooth muscle maturation.". Am. J. Respir. Cell Mol. Biol. 23 (2): 194–203. PMID 10919986.
Nimmrich I, Erdmann S, Melchers U, et al. (2000). "Seven genes that are differentially transcribed in colorectal tumor cell lines.". Cancer Lett. 160 (1): 37–43. PMID 11098082.
Hisaoka M, Wei-Qi S, Jian W, et al. (2003). "Specific but variable expression of h-caldesmon in leiomyosarcomas: an immunohistochemical reassessment of a novel myogenic marker.". Appl. Immunohistochem. Mol. Morphol. 9 (4): 302–8. PMID 11759055.