Barrier to autointegration factor 1

From Wikipedia, the free encyclopedia

PDB rendering based on 1ci4.

Available structures: 1ci4, 1qck, 2bzf, 2ezx, 2ezy, 2ezz, 2odg

Identifiers

Symbol(s)

BANF1; BAF; BCRP1; D14S1460; MGC111161

External IDs

OMIM: 603811 MGI: 1346330 HomoloGene: 2866

Gene ontology
Molecular Function:	• DNA binding
Cellular Component:	• nucleus • chromosome
Biological Process:	• response to virus • DNA integration

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003860 (mRNA)
NP_003851 (protein)

NM_001038231 (mRNA)
NP_001033320 (protein)

Location

Chr 11: 65.53 - 65.53 Mb

Chr 19: 5.36 - 5.37 Mb

Pubmed search

[1]

[2]

Barrier to autointegration factor 1, also known as BANF1, is a human gene.^[1]

The protein encoded by this gene was identified by its ability to protect retroviruses from intramolecular integration and therefore promote intermolecular integration into the host cell genome. The endogenous function of the protein is unknown. The protein forms a homodimer which localizes to the nucleus and is specifically associated with chromosomes during mitosis. This protein binds to DNA in a non-specific manner and studies in rodents suggest that it also binds to lamina-associated polypeptide 2, a component of the nuclear lamina.^[1]

[edit] See also

retroviral integration

[edit] References

^ ^a ^b Entrez Gene: BANF1 barrier to autointegration factor 1.

[edit] Further reading

Goldberg M, Harel A, Gruenbaum Y (2000). "The nuclear lamina: molecular organization and interaction with chromatin.". Crit. Rev. Eukaryot. Gene Expr. 9 (3-4): 285–93. PMID 10651245.
Segura-Totten M, Wilson KL (2004). "BAF: roles in chromatin, nuclear structure and retrovirus integration.". Trends Cell Biol. 14 (5): 261–6. doi:10.1016/j.tcb.2004.03.004. PMID 15130582.
Van Maele B, Debyser Z (2005). "HIV-1 integration: an interplay between HIV-1 integrase, cellular and viral proteins.". AIDS reviews 7 (1): 26–43. PMID 15875659.
Van Maele B, Busschots K, Vandekerckhove L, et al. (2006). "Cellular co-factors of HIV-1 integration.". Trends Biochem. Sci. 31 (2): 98–105. doi:10.1016/j.tibs.2005.12.002. PMID 16403635.
Lee MS, Craigie R (1994). "Protection of retroviral DNA from autointegration: involvement of a cellular factor.". Proc. Natl. Acad. Sci. U.S.A. 91 (21): 9823–7. PMID 7937898.
Lee MS, Craigie R (1998). "A previously unidentified host protein protects retroviral DNA from autointegration.". Proc. Natl. Acad. Sci. U.S.A. 95 (4): 1528–33. PMID 9465049.
Dear PH, Bankier AT, Piper MB (1998). "A high-resolution metric HAPPY map of human chromosome 14.". Genomics 48 (2): 232–41. doi:10.1006/geno.1997.5140. PMID 9521877.
Lynch RA, Piper M, Bankier A, et al. (1999). "Genomic and functional map of the chromosome 14 t(12;14) breakpoint cluster region in uterine leiomyoma.". Genomics 52 (1): 17–26. doi:10.1006/geno.1998.5406. PMID 9740667.
Cai M, Huang Y, Zheng R, et al. (1998). "Solution structure of the cellular factor BAF responsible for protecting retroviral DNA from autointegration.". Nat. Struct. Biol. 5 (10): 903–9. doi:10.1038/2345. PMID 9783751.
Furukawa K (1999). "LAP2 binding protein 1 (L2BP1/BAF) is a candidate mediator of LAP2-chromatin interaction.". J. Cell. Sci. 112 ( Pt 15): 2485–92. PMID 10393804.
Zheng R, Ghirlando R, Lee MS, et al. (2000). "Barrier-to-autointegration factor (BAF) bridges DNA in a discrete, higher-order nucleoprotein complex.". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 8997–9002. doi:10.1073/pnas.150240197. PMID 10908652.
Umland TC, Wei SQ, Craigie R, Davies DR (2000). "Structural basis of DNA bridging by barrier-to-autointegration factor.". Biochemistry 39 (31): 9130–8. PMID 10924106.
Harris D, Engelman A (2001). "Both the structure and DNA binding function of the barrier-to-autointegration factor contribute to reconstitution of HIV type 1 integration in vitro.". J. Biol. Chem. 275 (50): 39671–7. doi:10.1074/jbc.M002626200. PMID 11005805.
Lee KK, Haraguchi T, Lee RS, et al. (2002). "Distinct functional domains in emerin bind lamin A and DNA-bridging protein BAF.". J. Cell. Sci. 114 (Pt 24): 4567–73. PMID 11792821.
Haraguchi T, Koujin T, Segura-Totten M, et al. (2002). "BAF is required for emerin assembly into the reforming nuclear envelope.". J. Cell. Sci. 114 (Pt 24): 4575–85. PMID 11792822.
Segura-Totten M, Kowalski AK, Craigie R, Wilson KL (2002). "Barrier-to-autointegration factor: major roles in chromatin decondensation and nuclear assembly.". J. Cell Biol. 158 (3): 475–85. doi:10.1083/jcb.200202019. PMID 12163470.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Holaska JM, Lee KK, Kowalski AK, Wilson KL (2003). "Transcriptional repressor germ cell-less (GCL) and barrier to autointegration factor (BAF) compete for binding to emerin in vitro.". J. Biol. Chem. 278 (9): 6969–75. doi:10.1074/jbc.M208811200. PMID 12493765.
Lin CW, Engelman A (2003). "The barrier-to-autointegration factor is a component of functional human immunodeficiency virus type 1 preintegration complexes.". J. Virol. 77 (8): 5030–6. PMID 12663813.