Phosphatidylserine decarboxylase

From Wikipedia, the free encyclopedia

In enzymology, a phosphatidylserine decarboxylase (EC 4.1.1.65) is an enzyme that catalyzes the chemical reaction

phosphatidyl-L-serine phosphatidylethanolamine + CO₂

Hence, this enzyme has one substrate, phosphatidyl-L-serine, and two products, phosphatidylethanolamine and CO₂.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is phosphatidyl-L-serine carboxy-lyase (phosphatidylethanolamine-forming). Other names in common use include PS decarboxylase, and phosphatidyl-L-serine carboxy-lyase. This enzyme participates in glycine, serine and threonine metabolism and glycerophospholipid metabolism. It has 2 cofactors: pyridoxal phosphate, and Pyruvate.

[edit] References

• IUBMB entry for 4.1.1.65
• BRENDA references for 4.1.1.65 (Recommended.)
• PubMed references for 4.1.1.65
• PubMed Central references for 4.1.1.65
• Google Scholar references for 4.1.1.65
• KANFER J, KENNEDY EP (1964). "METABOLISM AND FUNCTION OF BACTERIAL LIPIDS. II. BIOSYNTHESIS OF PHOSPHOLIPIDS IN ESCHERICHIA COLI". J. Biol. Chem. 239: 1720–6. PMID 14213340. 
• Satre M, Kennedy EP (1978). "Identification of bound pyruvate essential for the activity of phosphatidylserine decarboxylase of Escherichia coli". J. Biol. Chem. 253: 479–83. PMID 338609. 

[edit] External links

The CAS registry number for this enzyme class is 9054-78-8.

• IUBMB entry for 4.1.1.65

• KEGG entry for 4.1.1.65

• BRENDA entry for 4.1.1.65

• NiceZyme view of 4.1.1.65

• EC2PDB: PDB structures for 4.1.1.65

• PRIAM entry for 4.1.1.65

• PUMA2 entry for 4.1.1.65

• IntEnz: Integrated Enzyme entry for 4.1.1.65

• MetaCyc entry for 4.1.1.65

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004609: phosphatidylserine decarboxylase

• AMIGO entry for GO code 0004609: phosphatidylserine decarboxylase