Phosphatidylinositol N-acetylglucosaminyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a phosphatidylinositol N-acetylglucosaminyltransferase (EC 2.4.1.198) is an enzyme that catalyzes the chemical reaction

UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol $\rightleftharpoons$ UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol

Thus, the two substrates of this enzyme are UDP-N-acetyl-D-glucosamine and 1-phosphatidyl-1D-myo-inositol, whereas its two products are UDP and 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-N-acetyl-D-glucosamine:1-phosphatidyl-1D-myo-inositol 6-(N-acetyl-alpha-D-glucosaminyl)transferase. Other names in common use include UDP-N-acetyl-D-glucosamine:phosphatidylinositol, N-acetyl-D-glucosaminyltransferase, uridine diphosphoacetylglucosamine, and alpha1,6-acetyl-D-glucosaminyltransferase. This enzyme participates in 3 metabolic pathways: glycosylphosphatidylinositol(gpi)-anchor, [[]], and glycan structures - biosynthesis 2.

[edit] References

IUBMB entry for 2.4.1.198
BRENDA references for 2.4.1.198 (Recommended.)
PubMed references for 2.4.1.198
PubMed Central references for 2.4.1.198
Google Scholar references for 2.4.1.198
Doering TL, Masterson WJ, Englund PT, Hart GW (1989). "Biosynthesis of the glycosyl phosphatidylinositol membrane anchor of the trypanosome variant surface glycoprotein. Origin of the non-acetylated glucosamine". J. Biol. Chem. 264: 11168–73. PMID 2525555.
Kinoshita T (1998). "The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1". EMBO. J. 17: 877–85. PMID 9463366.
K, Julius M, Kinoshita T (2000). "Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2". EMBO. J. 19: 4402–11. PMID 10944123.