Phosphatidylinositol (3,5)-bisphosphate

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Phosphatidylinositol (3,5)-bisphosphate (PtdIns(3,5)P₂) is a minor phospholipid component of cell membranes, yet important in distinguishing cell compartments. The generation of PtdIns(3,5)P₂ in internal membranes by the lipid kinase PIKfyve recruits a number of important proteins involved in regulating intracellular trafficking.

PtdIns(3,5)P₂ is dephophosphorylated by members of the myotubularin lipid phosphatase family on the 3 position of the inositol ring generating Phosphatidylinositol 5-phosphate (PtdIns5P).

The phosphoinositide-binding domain in a number of proteins binds to PtdIns(3,5)P₂, including the PH domain in centaurin-β2, the PX domain of SNX1, and a novel domain in Atg18p.

[edit] References

• Michell RH, Heath VL, Lemmon MA, Dove SK. (2006) Phosphatidylinositol 3,5-bisphosphate: metabolism and cellular functions. Trends Biochem Sci. 31(1):52-63. [1]

[edit] External links

• MeSH phosphatidylinositol+3,5-bisphosphate

v • d • e Lipids: phospholipids Glycerol backbone (Glycerophospholipids/ Phosphoglycerides) Phosphatidyl-: -ethanolamine/cephalin - -choline/lechithin (dipalmitoyl-) - -serine - -glycerol - -inositol (glyco-) phosphatidylinositol phosphates: PIP1 - PIP2 (3,4, 3,5, 4,5) - PIP3 Cardiolipin Ether lipids: Plasmalogen (Platelet-activating factor) Sphingosine backbone Sphingomyelin