2-dehydro-3-deoxyglucarate aldolase

From Wikipedia, the free encyclopedia

In enzymology, a 2-dehydro-3-deoxyglucarate aldolase (EC 4.1.2.20) is an enzyme that catalyzes the chemical reaction

2-dehydro-3-deoxy-D-glucarate pyruvate + tartronate semialdehyde

Hence, this enzyme has one substrate, 2-dehydro-3-deoxy-D-glucarate, and two products, pyruvate and tartronate semialdehyde.

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase (pyruvate-forming). Other names in common use include 2-keto-3-deoxyglucarate aldolase, alpha-keto-beta-deoxy-D-glucarate aldolase, and 2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase. This enzyme participates in ascorbate and aldarate metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1DXE, 1DXF, 1W37, 1W3I, 1W3N, and 1W3T.

[edit] References

• IUBMB entry for 4.1.2.20
• BRENDA references for 4.1.2.20 (Recommended.)
• PubMed references for 4.1.2.20
• PubMed Central references for 4.1.2.20
• Google Scholar references for 4.1.2.20
• Fish DC and Blumenthal HJ (1966). "2-Keto-3-deoxy-D-glucarate aldolase". Methods Enzymol. 9: 529–534. 

[edit] External links

The CAS registry number for this enzyme class is 37290-56-5.

• IUBMB entry for 4.1.2.20

• KEGG entry for 4.1.2.20

• BRENDA entry for 4.1.2.20

• NiceZyme view of 4.1.2.20

• EC2PDB: PDB structures for 4.1.2.20

• PRIAM entry for 4.1.2.20

• PUMA2 entry for 4.1.2.20

• IntEnz: Integrated Enzyme entry for 4.1.2.20

• MetaCyc entry for 4.1.2.20

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008672: 2-dehydro-3-deoxyglucarate aldolase

• AMIGO entry for GO code 0008672: 2-dehydro-3-deoxyglucarate aldolase