2-dehydro-3-deoxy-phosphogluconate aldolase

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In enzymology, a 2-dehydro-3-deoxy-phosphogluconate aldolase (EC 4.1.2.14) is an enzyme that catalyzes the chemical reaction

2-dehydro-3-deoxy-D-gluconate 6-phosphate $\rightleftharpoons$ pyruvate + D-glyceraldehyde 3-phosphate

Hence, this enzyme has one substrate, 2-dehydro-3-deoxy-D-gluconate 6-phosphate, and two products, pyruvate and D-glyceraldehyde 3-phosphate.

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 2-dehydro-3-deoxy-D-gluconate-6-phosphate D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming). Other names in common use include phospho-2-keto-3-deoxygluconate aldolase, KDPG aldolase, phospho-2-keto-3-deoxygluconic aldolase, 2-keto-3-deoxy-6-phosphogluconic aldolase, 2-keto-3-deoxy-6-phosphogluconate aldolase, 6-phospho-2-keto-3-deoxygluconate aldolase, ODPG aldolase, 2-oxo-3-deoxy-6-phosphogluconate aldolase, 2-keto-3-deoxygluconate-6-P-aldolase, 2-keto-3-deoxygluconate-6-phosphate aldolase, 2-dehydro-3-deoxy-D-gluconate-6-phosphate, and D-glyceraldehyde-3-phosphate-lyase. This enzyme participates in 3 metabolic pathways: pentose phosphate pathway, pentose and glucuronate interconversions, and arginine and proline metabolism.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 13 structures have been solved for this class of enzymes, with PDB accession codes 1EUA, 1EUN, 1FQ0, 1FWR, 1KGA, 1MXS, 1WA3, 1WAU, 1WBH, 2C0A, 2NUW, 2NUX, and 2NUY.