Phosphoglucosamine mutase

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In enzymology, a phosphoglucosamine mutase (EC 5.4.2.10) is an enzyme that catalyzes the chemical reaction

alpha-D-glucosamine 1-phosphate $\rightleftharpoons$ D-glucosamine 6-phosphate

Hence, this enzyme has one substrate, alpha-D-glucosamine 1-phosphate, and one product, D-glucosamine 6-phosphate.

This enzyme belongs to the family of isomerases, specifically the phosphotransferases (phosphomutases), which transfer phosphate groups within a molecule. The systematic name of this enzyme class is alpha-D-glucosamine 1,6-phosphomutase. This enzyme participates in aminosugars metabolism.

[edit] References

IUBMB entry for 5.4.2.10
BRENDA references for 5.4.2.10 (Recommended.)
PubMed references for 5.4.2.10
PubMed Central references for 5.4.2.10
Google Scholar references for 5.4.2.10
Mengin-Lecreulx D, van Heijenoort J (1996). "Characterization of the essential gene glmM encoding phosphoglucosamine mutase in Escherichia coli". J. Biol. Chem. 271: 32–9. PMID 8550580.
De Reuse H, Labigne A, Mengin-Lecreulx D (1997). "The Helicobacter pylori ureC gene codes for a phosphoglucosamine mutase". J. Bacteriol. 179: 3488–93. PMID 9171391.
Tomasz A (1997). "The femR315 gene from Staphylococcus aureus, the interruption of which results in reduced methicillin resistance, encodes a phosphoglucosamine mutase". J. Bacteriol. 179: 5321–5. PMID 9286983.
Mengin-Lecreulx D (1999). "Reaction mechanism of phosphoglucosamine mutase from Escherichia coli". Eur. J. Biochem. 262: 202–10. PMID 10231382.
Jolly L, Pompeo F, van Heijenoort J, Fassy F, Mengin-Lecreulx D (2000). "Autophosphorylation of phosphoglucosamine mutase from Escherichia coli". J. Bacteriol. 182: 1280–5. PMID 10671448.