Methylaspartate mutase
From Wikipedia, the free encyclopedia
In enzymology, a methylaspartate mutase (EC 5.4.99.1) is an enzyme that catalyzes the chemical reaction
- L-threo-3-methylaspartate
L-glutamate
Hence, this enzyme has one substrate, L-threo-3-methylaspartate, and one product, L-glutamate.
This enzyme belongs to the family of isomerases, specifically those intramolecular transferases transferring other groups. The systematic name of this enzyme class is L-threo-3-methylaspartate carboxy-aminomethylmutase. Other names in common use include glutamate mutase, glutamic mutase, glutamic isomerase, glutamic acid mutase, glutamic acid isomerase, methylaspartic acid mutase, beta-methylaspartate-glutamate mutase, and glutamate isomerase. This enzyme participates in c5-branched dibasic acid metabolism. It employs one cofactor, cobamide.
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[edit] Structural studies
As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 1B1A, 1BE1, 1CB7, 1CCW, 1FMF, 1I9C, 1ID8, and 2PWH.
[edit] References
- IUBMB entry for 5.4.99.1
- BRENDA references for 5.4.99.1 (Recommended.)
- PubMed references for 5.4.99.1
- PubMed Central references for 5.4.99.1
- Google Scholar references for 5.4.99.1
- BARKER HA, ROOZE V, SUZUKI F, IODICE AA (1964). "THE GLUTAMATE MUTASE SYSTEM. ASSAYS AND PROPERTIES". J. Biol. Chem. 239: 3260–6. PMID 14245371.
- Weissbach H, Toohey J and Barker HA (1959). "Isolation and properties of B12 coenzymes containing benzimidazole or dimethylbenzimidazole". Proc. Natl. Acad. Sci. USA 45: 521–528. doi:.
[edit] External links
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- The CAS registry number for this enzyme class is 9032-97-7.
[edit] Gene Ontology (GO) codes
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