Isobutyryl-CoA mutase

From Wikipedia, the free encyclopedia

In enzymology, an isobutyryl-CoA mutase (EC 5.4.99.13) is an enzyme that catalyzes the chemical reaction

2-methylpropanoyl-CoA butanoyl-CoA

Hence, this enzyme has one substrate, 2-methylpropanoyl-CoA, and one product, butanoyl-CoA.

This enzyme belongs to the family of isomerases, specifically those intramolecular transferases transferring other groups. The systematic name of this enzyme class is 2-methylpropanoyl-CoA CoA-carbonylmutase. Other names in common use include isobutyryl coenzyme A mutase, and butyryl-CoA:isobutyryl-CoA mutase. It has 2 cofactors: cobalt, and Cobamide coenzyme.

[edit] References

• IUBMB entry for 5.4.99.13
• BRENDA references for 5.4.99.13 (Recommended.)
• PubMed references for 5.4.99.13
• PubMed Central references for 5.4.99.13
• Google Scholar references for 5.4.99.13
• Willenbrock F and Robinson JA (1988). "The enzymic interconversion of isobutyryl and N-butyrylcarba(dethia)-coenzyme-A - a coenzyme-B12-dependent carbon skeleton rearrangement". Angew. Chem. Int. Ed. Engl. 27: 1089–1091. doi:10.1002/anie.198810891. 

[edit] External links

• IUBMB entry for 5.4.99.13

• KEGG entry for 5.4.99.13

• BRENDA entry for 5.4.99.13

• NiceZyme view of 5.4.99.13

• EC2PDB: PDB structures for 5.4.99.13

• PRIAM entry for 5.4.99.13

• PUMA2 entry for 5.4.99.13

• IntEnz: Integrated Enzyme entry for 5.4.99.13

• MetaCyc entry for 5.4.99.13

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047727: isobutyryl-CoA mutase

• AMIGO entry for GO code 0047727: isobutyryl-CoA mutase