Citrate-CoA ligase

From Wikipedia, the free encyclopedia

In enzymology, a citrate-CoA ligase (EC 6.2.1.18) is an enzyme that catalyzes the chemical reaction

ATP + citrate + CoA ADP + phosphate + (3S)-citryl-CoA

The 3 substrates of this enzyme are ATP, citrate, and CoA, whereas its 3 products are ADP, phosphate, and (3S)-citryl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is citrate:CoA ligase (ADP-forming). Other names in common use include citryl-CoA synthetase, citrate:CoA ligase, and citrate thiokinase. This enzyme participates in citrate cycle (tca cycle).

[edit] References

• IUBMB entry for 6.2.1.18
• BRENDA references for 6.2.1.18 (Recommended.)
• PubMed references for 6.2.1.18
• PubMed Central references for 6.2.1.18
• Google Scholar references for 6.2.1.18
• Lill U, Schreil A, Eggerer H (1982). "Isolation of enzymically active fragments formed by limited proteolysis of ATP citrate lyase". Eur. J. Biochem. 125: 645–50. doi:10.1111/j.1432-1033.1982.tb06731.x. PMID 6749502. 
• Aoshima M, Ishii M, Igarashi Y (2004). "A novel enzyme, citryl-CoA synthetase, catalysing the first step of the citrate cleavage reaction in Hydrogenobacter thermophilus TK-6". Mol. Microbiol. 52: 751–61. doi:10.1111/j.1365-2958.2004.04009.x. PMID 15101981. 

[edit] External links

The CAS registry number for this enzyme class is 856428-87-0.

• IUBMB entry for 6.2.1.18

• KEGG entry for 6.2.1.18

• BRENDA entry for 6.2.1.18

• NiceZyme view of 6.2.1.18

• EC2PDB: PDB structures for 6.2.1.18

• PRIAM entry for 6.2.1.18

• PUMA2 entry for 6.2.1.18

• IntEnz: Integrated Enzyme entry for 6.2.1.18

• MetaCyc entry for 6.2.1.18

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047779: citrate-CoA ligase

• AMIGO entry for GO code 0047779: citrate-CoA ligase